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The effect of magnesium sulphate infusion on ex vivo platelet aggregation in 11 female Yorkshire swine was observed using platelet-rich plasma and different agonists (ADP 5 mM; ADP 10 mM and collagen 1 mg/ml). Infusion of 1 g MgSO4 over 1 h produced a significant decrease in platelet aggregability. A dose-dependent effect of different ADP concentrations on platelet aggregation was noticed. Platelet inhibition was most consistent when using ADP 5 mM. We estimate this concentration of agonist as optimal in swine. The swine model is a good choice for investigation of in vivo platelet activation, especially with regard to cardiovascular research. We conclude that there is an inhibitory effect of supplemental magnesium on ex vivo platelet aggregation in swine with initial normomagnesaemia.
W R Herzog, and
D Atar, and
P A Gurbel, and
R A Vogel, and
M L Schlossberg, and
V L Serebruany
March 2005,
Magnesium research,
W R Herzog, and
D Atar, and
P A Gurbel, and
R A Vogel, and
M L Schlossberg, and
V L Serebruany
February 2009,
Platelets,
W R Herzog, and
D Atar, and
P A Gurbel, and
R A Vogel, and
M L Schlossberg, and
V L Serebruany
April 1986,
Thrombosis research,
W R Herzog, and
D Atar, and
P A Gurbel, and
R A Vogel, and
M L Schlossberg, and
V L Serebruany
January 1991,
Agents and actions. Supplements,
W R Herzog, and
D Atar, and
P A Gurbel, and
R A Vogel, and
M L Schlossberg, and
V L Serebruany
December 1994,
Thrombosis and haemostasis,
W R Herzog, and
D Atar, and
P A Gurbel, and
R A Vogel, and
M L Schlossberg, and
V L Serebruany
October 1987,
Arzneimittel-Forschung,
W R Herzog, and
D Atar, and
P A Gurbel, and
R A Vogel, and
M L Schlossberg, and
V L Serebruany
March 1996,
European journal of medical research,
W R Herzog, and
D Atar, and
P A Gurbel, and
R A Vogel, and
M L Schlossberg, and
V L Serebruany
August 1982,
Thrombosis research,
W R Herzog, and
D Atar, and
P A Gurbel, and
R A Vogel, and
M L Schlossberg, and
V L Serebruany
January 1984,
Folia haematologica (Leipzig, Germany : 1928),
W R Herzog, and
D Atar, and
P A Gurbel, and
R A Vogel, and
M L Schlossberg, and
V L Serebruany
May 2011,
Journal of thrombosis and thrombolysis,
