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A 43-yr-old caucasian female presented in July 1992 with an explosive onset of diffuse scleroderma following general anaesthesia for orthopaedic surgery. Her environmental exposures included silicone breast prosthetic surgery and silica exposure, both preceding development of scleroderma. She was DR5-negative, DRw52 positive. All currently available literature relating to breast implants and scleroderma is reviewed and the conclusion drawn that, for currently documented US data, there is no evidence to suggest that patients having had breast augmentation have rates of scleroderma higher than expected to chance alone. However the cause-effect relationship between silicone and scleroderma/other connective tissue disease requires, not just anecdotal reports, but a rigorously designed study.
H J Englert, and
G B Howe, and
R Penny, and
P Brooks
September 1997,
The Western journal of medicine,
H J Englert, and
G B Howe, and
R Penny, and
P Brooks
April 1994,
Lancet (London, England),
H J Englert, and
G B Howe, and
R Penny, and
P Brooks
June 2022,
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases,
H J Englert, and
G B Howe, and
R Penny, and
P Brooks
March 1992,
Plastic and reconstructive surgery,
H J Englert, and
G B Howe, and
R Penny, and
P Brooks
August 1992,
Ugeskrift for laeger,
H J Englert, and
G B Howe, and
R Penny, and
P Brooks
July 2015,
QJM : monthly journal of the Association of Physicians,
H J Englert, and
G B Howe, and
R Penny, and
P Brooks
May 1992,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
H J Englert, and
G B Howe, and
R Penny, and
P Brooks
June 1992,
The Medical journal of Australia,
H J Englert, and
G B Howe, and
R Penny, and
P Brooks
April 1992,
The Medical journal of Australia,
H J Englert, and
G B Howe, and
R Penny, and
P Brooks
December 1989,
Ugeskrift for laeger,
