-transparent.png){kind=logo}
The inhibitory effects of volatile and local, but not intravenous, anesthetics on endothelium-dependent relaxations of blood vessels have been demonstrated in vitro by several investigators. The aim of this study was to determine the effects of barbiturates on endothelium-dependent arterial relaxation and elucidate the mechanism(s) responsible. Canine mesenteric arteries and rat aortae were isolated, and tension changes in helical strips were recorded. Endothelium-dependent relaxations elicited by acetylcholine and bradykinin in canine mesenteric arteries, and those by acetylcholine in rat aortae, were significantly attenuated by thiopental (3 x 10(-4) M) pretreatment. Sodium nitroprusside (SNP)-induced, endothelium-independent relaxations were significantly attenuated by thiopental (10(-4)-3 x 10(-4) M). The effects of pentobarbital were less marked than those of thiopental. Acetylcholine (10(-5) M)-stimulated levels of 3',5'-cyclic guanosine monophosphate (cGMP) in rat aortae were reduced significantly by thiopental and pentobarbital (both 10(-3) M), and SNP (3 x 10(-7) M)-stimulated levels were reduced by thiopental (3 x 10(-4)-10(-3) M) and pentobarbital (10(-3) M). We conclude that barbiturates inhibit cGMP-mediated endothelium-dependent and independent arterial relaxations. Inhibition of endothelium-dependent relaxation by barbiturates may be mediated by their effects on vascular smooth muscle itself and not on endothelium.
K Terasako, and
K Nakamura, and
H Toda, and
M Kakuyama, and
Y Hatano, and
K Mori
January 1995,
Life sciences,
K Terasako, and
K Nakamura, and
H Toda, and
M Kakuyama, and
Y Hatano, and
K Mori
January 1983,
Transactions of the Association of American Physicians,
K Terasako, and
K Nakamura, and
H Toda, and
M Kakuyama, and
Y Hatano, and
K Mori
January 1989,
British journal of clinical pharmacology,
K Terasako, and
K Nakamura, and
H Toda, and
M Kakuyama, and
Y Hatano, and
K Mori
January 1991,
Life sciences,
K Terasako, and
K Nakamura, and
H Toda, and
M Kakuyama, and
Y Hatano, and
K Mori
March 1999,
The Chinese journal of physiology,
K Terasako, and
K Nakamura, and
H Toda, and
M Kakuyama, and
Y Hatano, and
K Mori
January 1991,
Blood vessels,
K Terasako, and
K Nakamura, and
H Toda, and
M Kakuyama, and
Y Hatano, and
K Mori
December 1995,
Circulation,
K Terasako, and
K Nakamura, and
H Toda, and
M Kakuyama, and
Y Hatano, and
K Mori
January 1983,
Nature,
K Terasako, and
K Nakamura, and
H Toda, and
M Kakuyama, and
Y Hatano, and
K Mori
July 1990,
The American journal of physiology,
K Terasako, and
K Nakamura, and
H Toda, and
M Kakuyama, and
Y Hatano, and
K Mori
April 1999,
Indian journal of experimental biology,
