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A case of a 4-year-old child with disseminated lymphosarcoma with meningeal involvement is described. Immunological investigations of the blast cells in the cerebrospinal fluid were carried out and in most of them Ig determinants and no response to PHA stimulation were found. So the B-dependent nature of these cells was ascertained. This observation is a contribution to the diagnosis of lymphoid malignancies through the evaluation of the immunological nature of the blast cells. The data of the literature are still scarce and inconclusive.
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