-transparent.png){kind=logo}
Phosphine (PH3) is a highly toxic grain fumigant that can be produced from the reaction of metal phosphides with water. To determine the in vivo cytogenetic effects of inhalation of PH3, male CD-1 mice were exposed to either 0, 5, 10, or 15 ppm target concentrations of PH3 for 6 hr. Twenty hours after the termination of exposure, the spleens of the mice were removed, macerated, and the splenocytes cultured for analyses of sister chromatid exchanges, chromosome aberrations, and micronuclei in cytochalasin B-induced binucleated cells. In addition, bone marrow smears were made for the analysis of micronuclei in polychromatic erythrocytes. No increase in any of the cytogenetic endpoints was found at any of the concentrations examined. The only statistically significant response was a concentration-related slowing of the cell cycle in the splenocytes.
A D Kligerman, and
M F Bryant, and
C L Doerr, and
G L Erexson, and
P Kwanyuen, and
J K McGee
January 1994,
Environmental and molecular mutagenesis,
A D Kligerman, and
M F Bryant, and
C L Doerr, and
G L Erexson, and
P Kwanyuen, and
J K McGee
January 1993,
IARC scientific publications,
A D Kligerman, and
M F Bryant, and
C L Doerr, and
G L Erexson, and
P Kwanyuen, and
J K McGee
September 1996,
Mutation research,
A D Kligerman, and
M F Bryant, and
C L Doerr, and
G L Erexson, and
P Kwanyuen, and
J K McGee
August 2019,
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,
A D Kligerman, and
M F Bryant, and
C L Doerr, and
G L Erexson, and
P Kwanyuen, and
J K McGee
October 1973,
Toxicology and applied pharmacology,
A D Kligerman, and
M F Bryant, and
C L Doerr, and
G L Erexson, and
P Kwanyuen, and
J K McGee
January 1994,
Environmental and molecular mutagenesis,
A D Kligerman, and
M F Bryant, and
C L Doerr, and
G L Erexson, and
P Kwanyuen, and
J K McGee
March 2023,
International journal of environmental research and public health,
A D Kligerman, and
M F Bryant, and
C L Doerr, and
G L Erexson, and
P Kwanyuen, and
J K McGee
October 1989,
Journal of the National Cancer Institute,
A D Kligerman, and
M F Bryant, and
C L Doerr, and
G L Erexson, and
P Kwanyuen, and
J K McGee
January 1986,
Environmental mutagenesis,
A D Kligerman, and
M F Bryant, and
C L Doerr, and
G L Erexson, and
P Kwanyuen, and
J K McGee
January 1978,
Archives of environmental health,
