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The purpose of this study was to investigate the energetic metabolism in obese Zucker rats, using phosphorus nuclear magnetic resonance spectroscopy at rest and during a 2-Hz muscle stimulation and subsequent recovery. Animals were anesthetized with ketamine (150 mg/kg ip). Fed obese rats and 2-day-fasted obese rats were compared with their normally fed and 2-day-fasted lean litter mates. No differences were found between the two groups for ATP, total creatine, phosphocreatine (PCr), and intracellular pH. Starvation in lean rats resulted in a significant fall in inorganic phosphate (Pi), increased resting ADP level, and decreased PCr and ADP recovery after stimulation. The obese rats exhibited a decreased PCr/Pi and increased ADP at rest and a decreased PCr resynthesis and ADP metabolization rate after stimulation. Muscle stimulation in fasted obese rats induced higher PCr depletion and more pronounced acidosis. These results suggest an in vivo mitochondrial metabolism dysfunction in fasted lean as well as in fed and fasted obese rats.
M Klein, and
P Kaminsky, and
P M Walker, and
J Straczek, and
F Barbe, and
M Duc, and
C Burlet
November 2003,
American journal of physiology. Regulatory, integrative and comparative physiology,
M Klein, and
P Kaminsky, and
P M Walker, and
J Straczek, and
F Barbe, and
M Duc, and
C Burlet
January 1983,
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M Klein, and
P Kaminsky, and
P M Walker, and
J Straczek, and
F Barbe, and
M Duc, and
C Burlet
March 1997,
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
M Klein, and
P Kaminsky, and
P M Walker, and
J Straczek, and
F Barbe, and
M Duc, and
C Burlet
October 2001,
Journal of applied physiology (Bethesda, Md. : 1985),
M Klein, and
P Kaminsky, and
P M Walker, and
J Straczek, and
F Barbe, and
M Duc, and
C Burlet
June 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
M Klein, and
P Kaminsky, and
P M Walker, and
J Straczek, and
F Barbe, and
M Duc, and
C Burlet
August 2010,
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M Klein, and
P Kaminsky, and
P M Walker, and
J Straczek, and
F Barbe, and
M Duc, and
C Burlet
July 1980,
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M Klein, and
P Kaminsky, and
P M Walker, and
J Straczek, and
F Barbe, and
M Duc, and
C Burlet
November 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
M Klein, and
P Kaminsky, and
P M Walker, and
J Straczek, and
F Barbe, and
M Duc, and
C Burlet
September 1988,
The American journal of physiology,
M Klein, and
P Kaminsky, and
P M Walker, and
J Straczek, and
F Barbe, and
M Duc, and
C Burlet
July 2014,
American journal of physiology. Endocrinology and metabolism,
