BIOMAT Database Logo BIOMAT Database Logo

Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects. 1994

E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Department of Psychiatry, New York University Medical Center, NY 10016.

OBJECTIVE Positron emission tomography and the fluorodeoxyglucose (FDG) method were used to determine the brain's metabolic response to neuroleptic challenge in a normal, disease-free state. METHODS FDG measurements were obtained before and 12 hours after administration of 5 mg of haloperidol to 12 young normal men. These values were compared with test-retest FDG measures obtained from nine normal male control subjects who received no drug intervention. RESULTS After haloperidol administration, the haloperidol subjects showed significantly lower glucose utilization in the neocortex, limbic cortex, thalamus, and caudate nucleus but not in the putamen or cerebellum. After adjustment for global effects, significant reductions were still evident in the frontal, occipital, and anterior cingulate cortex, whereas the putamen and cerebellum showed significant increases. CONCLUSIONS This study, measuring the brain's metabolic response to acute receptor blockade, is a first step in the development of an assay of CNS pharmacological activity. By determining the response to neuroleptic challenge in a normal state, the study establishes a comparison group for determining response to challenge in various psychiatric conditions.

UI MeSH Term Description Entries
D008032 Limbic System A set of forebrain structures common to all mammals that is defined functionally and anatomically. It is implicated in the higher integration of visceral, olfactory, and somatic information as well as homeostatic responses including fundamental survival behaviors (feeding, mating, emotion). For most authors, it includes the AMYGDALA; EPITHALAMUS; GYRUS CINGULI; hippocampal formation (see HIPPOCAMPUS); HYPOTHALAMUS; PARAHIPPOCAMPAL GYRUS; SEPTAL NUCLEI; anterior nuclear group of thalamus, and portions of the basal ganglia. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p744; NeuroNames, http://rprcsgi.rprc.washington.edu/neuronames/index.html (September 2, 1998)). Limbic Systems,System, Limbic,Systems, Limbic
D008297 Male Males
D011699 Putamen The largest and most lateral of the BASAL GANGLIA lying between the lateral medullary lamina of the GLOBUS PALLIDUS and the EXTERNAL CAPSULE. It is part of the neostriatum and forms part of the LENTIFORM NUCLEUS along with the GLOBUS PALLIDUS. Nucleus Putamen,Nucleus Putamens,Putamen, Nucleus,Putamens,Putamens, Nucleus
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002531 Cerebellum The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills. Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D003847 Deoxyglucose 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity. 2-Deoxy-D-glucose,2-Deoxyglucose,2-Desoxy-D-glucose,2 Deoxy D glucose,2 Deoxyglucose,2 Desoxy D glucose
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006220 Haloperidol A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) Haldol
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Effects of sufentanil on regional cerebral glucose utilization in rats.
November 1984, Anesthesiology,
E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Acute effects of haloperidol on cerebral cortex blood flow in normal and schizophrenic subjects.
October 1996, Biological psychiatry,
E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Cerebral metabolism of isotopic glucose in normal human subjects.
January 1957, Journal of applied physiology,
E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Effects of smoking on regional cerebral blood flow in neurologically normal subjects.
January 1983, Stroke,
E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Regional cerebral glucose utilization during hyperglycemia.
March 1987, Journal of neurochemistry,
E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Methylphenidate decreases regional cerebral blood flow in normal human subjects.
January 1994, Life sciences,
E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Differential effects of acute administration of clozapine or haloperidol on local cerebral glucose utilization in the rat.
September 1997, Brain research,
E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Prolonged adverse effects of haloperidol in normal subjects.
September 1981, The New England journal of medicine,
E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Acute d-amphetamine challenge in schizophrenia: effects on cerebral glucose utilization and clinical symptomatology.
September 1994, Biological psychiatry,
E J Bartlett, and J D Brodie, and P Simkowitz, and S L Dewey, and H Rusinek, and A P Wolf, and J S Fowler, and N D Volkow, and G Smith, and A Wolkin
Effects of smoking on regional cerebral blood flow in cerebral vascular disease patients and normal subjects.
March 1987, The Tohoku journal of experimental medicine,
Copied contents to your clipboard!