Refinements of an isoelectric focusing multi-enzyme phenotyping system. 1994

A Zamir, and A Marbach
Forensic Biology Laboratory, Israel Police Headquarters, Jerusalem.

Several modifications have been made to a system of simultaneous phenotyping of EAP, EsD, PGM and ADA in bloodstains by isoelectric focusing, which improved the results of the system. An increase in the thickness of the gel improved the resolution of the isozymes' bands, especially PGM and EAP, and diminished the effect of overloading. By increasing the width of the gel it was possible to increase the number of samples applied to the gel. By coating one of the glass plates, used in the preparation of the gels, with a hydrophobic solution, separation of the plate from the gel was greatly facilitated. Finally, the system was found to be very useful as a rapid screening method prior to DNA testing.

UI MeSH Term Description Entries
D007525 Isoelectric Focusing Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point. Electrofocusing,Focusing, Isoelectric
D007527 Isoenzymes Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics. Alloenzyme,Allozyme,Isoenzyme,Isozyme,Isozymes,Alloenzymes,Allozymes
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D001801 Blood Stains Antigenic characteristics and DNA fingerprint patterns identified from blood stains. Their primary value is in criminal cases. Blood Stain,Stain, Blood,Stains, Blood
D005554 Forensic Medicine The application of medical knowledge to questions of law. Legal Medicine,Medicine, Forensic,Medicine, Legal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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