Biomaterial Database

Sodium fluoride sustained-release bone cement: an experimental study in vitro and in vivo. 1994

B Magnan, and C Gabbi, and D Regis

University of Verona, Institute of Clinical Orthopedics and Traumatology, Italy.

A new "low temperature" bone cement, consisting of polymethylmethacrylate (PMMA) and 6% sodium fluoride, was developed for use in orthopedics. Fluoride is a well-known agent that may stimulate osteoblast activity and differentiation in vitro and in vivo; for this reason fluoride has been used for 30 years in the treatment of osteoporotic diseases of the bone. A local effect obtained with a slow release of fluoride from bone cement at the interface between bone and prosthetic implants could potentially enhance new bone formation around the prosthesis. This material was investigated both "in vitro", by establishing the kinetics of fluoride release from the acrylic bone cement and its maximal compressive strength, and "in vivo", by fitting 24 rabbits, which were then killed after 4, 12 and 16 weeks, with femoral implants, following labelling with fluorescent stains to allow the histologic evaluation of bone remodelling. The "in vitro" study revealed the release kinetics of fluoride from bone cement and the compressive strength of PMMA, that is not affected by the addition of fluoride. The "in vivo" investigation showed considerable healing ability after surgical and heat trauma, and new bone formation that appears larger on the surface in contact with fluoridated cement.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008768	Methylmethacrylates	The methyl esters of methacrylic acid that polymerize easily and are used as tissue cements, dental materials, and absorbent for biological substances.
D008859	Microscopy, Polarization	Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.	Microscopy, Polarized Light,Polarization Microscopy,Light Microscopies, Polarized,Light Microscopy, Polarized,Microscopies, Polarization,Microscopies, Polarized Light,Polarization Microscopies,Polarized Light Microscopies,Polarized Light Microscopy
D008860	Microscopy, Ultraviolet	Microscopy in which the image is formed by ultraviolet radiation and is displayed and recorded by means of photographic film.	Ultraviolet Microscopy,Microscopies, Ultraviolet,Ultraviolet Microscopies
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D001843	Bone Cements	Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.	Bone Cement,Bone Glues,Bone Pastes,Bone Glue,Bone Paste,Cement, Bone,Cements, Bone,Glue, Bone,Glues, Bone,Paste, Bone,Pastes, Bone
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012969	Sodium Fluoride	A source of inorganic fluoride which is used topically to prevent dental caries.	Fluoristat,Ossin,Zymafluor,Fluoride, Sodium,Fluorides, Sodium,Fluoristats,Ossins,Sodium Fluorides,Zymafluors
D013718	Tensile Strength	The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)	Strength, Tensile,Strengths, Tensile,Tensile Strengths
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In