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Antibodies against the P1 antigen of the P blood group system have been found in 34% of P2 pigeon breeders' sera and in only 6% of the control group. In pigeon breeders, this anti-P1 activity correlates with immunization to pigeon serum and can consistently be removed by absorption with pigeon erythrocytes, serum or droppings. It is concluded that P1 or a related antigen is present in the pigeon blood and drop-pings and that heavy exposure to pigeon dust, as may occur in pigeon breeders, is one of the factors capable of inducing IgM antibodies to P1 antigen. The clinical importance of this finding remains to be defined.
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