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Adenocarcinoma of the prostate is the second leading cause of cancer deaths in men. The protein kinase C (PKC) family of signal transducing kinases has been implicated in neoplastic transformation and progression in other tissues, and some evidence suggests roles for PKC in prostate growth and neoplasia. We have detected expression of eight specific PKC isozyme mRNAs (alpha, beta, gamma, delta, epsilon, eta, theta, and zeta) in normal rat whole prostate and found some of these to be differentially expressed in certain Dunning R-3327 rat prostatic adenocarcinoma sublines. PKC zeta mRNA was detected in normal prostate and Dunning H tumor, whereas an alternatively spliced form of PKC zeta RNA was found in Dunning G tumor and normal brain. Both forms of PKC zeta RNA were markedly reduced in the androgen insensitive, highly metastatic Dunning AT-3, MAT-Lu, and MAT-LyLu tumors. We have cloned and report the sequence of the novel portion of the alternatively spliced form of PKC zeta RNA, which is polyadenylated and present in cytoplasm.
C T Powell, and
W R Fair, and
W D Heston
February 1990,
Cancer research,
C T Powell, and
W R Fair, and
W D Heston
January 1991,
The Prostate,
C T Powell, and
W R Fair, and
W D Heston
April 1996,
Biochemical pharmacology,
C T Powell, and
W R Fair, and
W D Heston
January 1980,
Progress in clinical and biological research,
C T Powell, and
W R Fair, and
W D Heston
September 1978,
Cancer research,
C T Powell, and
W R Fair, and
W D Heston
June 1984,
Endocrinologia japonica,
C T Powell, and
W R Fair, and
W D Heston
January 1981,
Urological research,
C T Powell, and
W R Fair, and
W D Heston
August 1983,
Gan,
C T Powell, and
W R Fair, and
W D Heston
November 1978,
Cancer research,
C T Powell, and
W R Fair, and
W D Heston
January 1989,
The Prostate,
