Biomaterial Database

Plasma lipids and coronary atherosclerosis in Japanese men. 1993

Y Nakaya, and Y Hiasa, and S Morimoto

2nd Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.

Asians have lower plasma levels of cholesterol than Americans and Europeans, and few studies on lipids as predictors of coronary artery disease in Asians have been performed. Therefore, we analyzed the plasma lipids, lipoproteins and apolipoproteins in Japanese men with angiographically documented coronary artery disease (CAD). Plasma levels of lipids, lipoproteins and apolipoproteins from patients without CAD (33 males with no significant coronary artery stenosis) and patients with CAD (58 males with significant coronary artery stenosis) were compared. In addition, the relationship between plasma lipids and the severity of coronary artery stenosis was determined using a multivariate analysis. For Japanese men, plasma levels of cholesterol and triglycerides do not discriminate between patients with and without CAD. However, low density lipoprotein (LDL) and apoprotein A-1 are good predictors of coronary artery disease in Japanese men. The plasma levels of lipoproteins and apolipoproteins are good predictors of coronary artery disease in populations with a low fat intake and with normocholesteremia and normotriglycemia.

UI	MeSH Term	Description	Entries
D007564	Japan	A country in eastern Asia, island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. The capital is Tokyo.	Bonin Islands
D008055	Lipids	A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)	Lipid
D008074	Lipoproteins	Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.	Circulating Lipoproteins,Lipoprotein,Lipoproteins, Circulating
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D003324	Coronary Artery Disease	Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.	Arteriosclerosis, Coronary,Atherosclerosis, Coronary,Coronary Arteriosclerosis,Coronary Atherosclerosis,Left Main Coronary Artery Disease,Left Main Coronary Disease,Left Main Disease,Arterioscleroses, Coronary,Artery Disease, Coronary,Artery Diseases, Coronary,Atheroscleroses, Coronary,Coronary Arterioscleroses,Coronary Artery Diseases,Coronary Atheroscleroses,Left Main Diseases
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001053	Apolipoproteins	Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.	Apolipoprotein