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Twenty-five patients with acute lymphoblastic leukemia [15 adults and 10 children] received standard treatment in which regular L-asparaginase was replaced for L-asparaginase of prolonged action [PEG-asparaginase]. The drug was administered once in two weeks in a dose 2500 IU/m2 for remission induction and consolidation or as a component of maintenance therapy. It was found that the response to primary PEG-asparaginase treatment or its use in the disease relapses produced the same response as regular L-asparaginase, being superior in convenience and feasibility of outpatient use. Side effects in the form of hypoproteinemia, hepatic toxicity and toxic pancreatitis [in children, 9 and 1 adults, respectively] were moderate and disappeared after 10-20-day discontinuation of the drug.
M A Volkova, and
S A Maiakova, and
G I Kaletin, and
B V Kurdiukov, and
M A Frenkel', and
A K Protasova, and
N N Tupitsyn, and
E V Fleĭshman
May 2010,
Expert opinion on biological therapy,
M A Volkova, and
S A Maiakova, and
G I Kaletin, and
B V Kurdiukov, and
M A Frenkel', and
A K Protasova, and
N N Tupitsyn, and
E V Fleĭshman
September 2002,
Blood,
M A Volkova, and
S A Maiakova, and
G I Kaletin, and
B V Kurdiukov, and
M A Frenkel', and
A K Protasova, and
N N Tupitsyn, and
E V Fleĭshman
January 2022,
Leukemia research reports,
M A Volkova, and
S A Maiakova, and
G I Kaletin, and
B V Kurdiukov, and
M A Frenkel', and
A K Protasova, and
N N Tupitsyn, and
E V Fleĭshman
February 2022,
Clinical laboratory,
M A Volkova, and
S A Maiakova, and
G I Kaletin, and
B V Kurdiukov, and
M A Frenkel', and
A K Protasova, and
N N Tupitsyn, and
E V Fleĭshman
January 1998,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
M A Volkova, and
S A Maiakova, and
G I Kaletin, and
B V Kurdiukov, and
M A Frenkel', and
A K Protasova, and
N N Tupitsyn, and
E V Fleĭshman
July 2012,
Journal of pharmacology & pharmacotherapeutics,
M A Volkova, and
S A Maiakova, and
G I Kaletin, and
B V Kurdiukov, and
M A Frenkel', and
A K Protasova, and
N N Tupitsyn, and
E V Fleĭshman
January 2020,
Hematology, transfusion and cell therapy,
M A Volkova, and
S A Maiakova, and
G I Kaletin, and
B V Kurdiukov, and
M A Frenkel', and
A K Protasova, and
N N Tupitsyn, and
E V Fleĭshman
January 2022,
Frontiers in pediatrics,
M A Volkova, and
S A Maiakova, and
G I Kaletin, and
B V Kurdiukov, and
M A Frenkel', and
A K Protasova, and
N N Tupitsyn, and
E V Fleĭshman
February 1998,
Singapore medical journal,
M A Volkova, and
S A Maiakova, and
G I Kaletin, and
B V Kurdiukov, and
M A Frenkel', and
A K Protasova, and
N N Tupitsyn, and
E V Fleĭshman
November 2008,
Polskie Archiwum Medycyny Wewnetrznej,
