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"Autonomous" thyroid nodule is a localized nodular lesion of the thyroid gland characterized by growth, iodine uptake and function, all independent from TSH control. These nodules represent a heterogeneous anatomic and clinical entity. The clinical diagnosis is based upon a negative suppression of nodule iodine uptake and scan imaging by T3 administration. The nodule function is determined by high serum thyroid hormone levels and/or low TSH (measured by ultrasensitive assay). Etiology and pathogenesis of these nodules is not yet completely clarified. Both genetic and environmental factors determine nodule growth and function: thyroid cells, in fact, are genetically heterogeneous and may have intrinsic (congenital) characteristics that may promote the growth of cellular clones having mitotic and functional activity that is partially independent of TSH. In these particular cell clones, environmental factors like iodine deficiency or other goitrogens may favour the growth of autonomous nodules and also, by activating their function, may induce toxicity. The autonomous thyroid nodules need to be treated only when they become toxic: in this case both surgical excision or radioiodine may be used.
R Vigneri, and
R Catalfamo, and
V Freni, and
D Giuffrida, and
D Gullo, and
A Ippolito, and
P Iurato, and
S Tumino, and
G L La Rosa, and
C Regalbuto
May 2006,
Nihon rinsho. Japanese journal of clinical medicine,
R Vigneri, and
R Catalfamo, and
V Freni, and
D Giuffrida, and
D Gullo, and
A Ippolito, and
P Iurato, and
S Tumino, and
G L La Rosa, and
C Regalbuto
December 1993,
Minerva endocrinologica,
R Vigneri, and
R Catalfamo, and
V Freni, and
D Giuffrida, and
D Gullo, and
A Ippolito, and
P Iurato, and
S Tumino, and
G L La Rosa, and
C Regalbuto
December 1993,
Minerva endocrinologica,
R Vigneri, and
R Catalfamo, and
V Freni, and
D Giuffrida, and
D Gullo, and
A Ippolito, and
P Iurato, and
S Tumino, and
G L La Rosa, and
C Regalbuto
March 1968,
Archives of surgery (Chicago, Ill. : 1960),
R Vigneri, and
R Catalfamo, and
V Freni, and
D Giuffrida, and
D Gullo, and
A Ippolito, and
P Iurato, and
S Tumino, and
G L La Rosa, and
C Regalbuto
January 1999,
Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych,
R Vigneri, and
R Catalfamo, and
V Freni, and
D Giuffrida, and
D Gullo, and
A Ippolito, and
P Iurato, and
S Tumino, and
G L La Rosa, and
C Regalbuto
December 1983,
Medicina clinica,
R Vigneri, and
R Catalfamo, and
V Freni, and
D Giuffrida, and
D Gullo, and
A Ippolito, and
P Iurato, and
S Tumino, and
G L La Rosa, and
C Regalbuto
May 1990,
Clinical nuclear medicine,
R Vigneri, and
R Catalfamo, and
V Freni, and
D Giuffrida, and
D Gullo, and
A Ippolito, and
P Iurato, and
S Tumino, and
G L La Rosa, and
C Regalbuto
October 1996,
European journal of endocrinology,
R Vigneri, and
R Catalfamo, and
V Freni, and
D Giuffrida, and
D Gullo, and
A Ippolito, and
P Iurato, and
S Tumino, and
G L La Rosa, and
C Regalbuto
November 1974,
Archives of internal medicine,
R Vigneri, and
R Catalfamo, and
V Freni, and
D Giuffrida, and
D Gullo, and
A Ippolito, and
P Iurato, and
S Tumino, and
G L La Rosa, and
C Regalbuto
September 1967,
Annals of internal medicine,
