-transparent.png){kind=logo}
UBI4, the polyubiquitin gene of Saccharomyces cerevisiae, is expressed at a low level in vegetative cells, yet induced strongly in response to starvation, cadmium, DNA-damaging agents and heat shock. UBI4 is also expressed at a higher basal level in cells growing by respiration as compared to glucose-repressed cells growing by fermentation. This higher UBI4 expression of respiratory cultures probably helps to counteract the greater oxidative stress of respiratory growth. The effects of inactivating UBI4 on high temperature viability are more marked with respiratory cultures. Also loss of UBI4 leads to a considerably increased rate of killing of respiring cells by hydrogen peroxide, whereas the same gene inactivation has relatively little effect on the peroxide sensitivity of cells in which mitochondrial functions are repressed. This is the first study to reveal that ubiquitin levels in cells can influence their ability to withstand oxidative stress.
L Cheng, and
R Watt, and
P W Piper
June 2023,
Applied microbiology and biotechnology,
L Cheng, and
R Watt, and
P W Piper
June 1997,
FEBS letters,
L Cheng, and
R Watt, and
P W Piper
December 1998,
Yeast (Chichester, England),
L Cheng, and
R Watt, and
P W Piper
January 2017,
International journal of microbiology,
L Cheng, and
R Watt, and
P W Piper
May 1996,
Current genetics,
L Cheng, and
R Watt, and
P W Piper
December 2013,
FEMS yeast research,
L Cheng, and
R Watt, and
P W Piper
March 1997,
The EMBO journal,
L Cheng, and
R Watt, and
P W Piper
January 2007,
Applied biochemistry and biotechnology,
L Cheng, and
R Watt, and
P W Piper
January 2010,
Redox report : communications in free radical research,
L Cheng, and
R Watt, and
P W Piper
October 2010,
The FEBS journal,
