-transparent.png){kind=logo}
The biosynthesis of antitumor antibiotic cytogenin, 3-hydroxymethyl-6-methoxy-8-hydroxy-isocoumarin, was studied by feeding 14C- or 13C-labeled compounds to culture of the producing organism, Streptoverticillium eurocidicum MI43-37F11. 14C-Acetate and 14C-methionine were efficiently incorporated into cytogenin as precursors. 13C NMR studies proved that the carbon skeleton of cytogenin is derived from pentaketide intermediate due to head-to-tail condensation of five acetate units and methyl group of 6-OCH3 is derived from methionine. It was suggested that 3-hydroxymethyl and/or 6-methoxy group of cytogenin were metabolized by hydroxylation and/or methylation from three intermediates.
H Kumagai, and
M Amemiya, and
H Naganawa, and
T Sawa, and
M Ishizuka, and
T Takeuchi
February 1995,
The Journal of antibiotics,
H Kumagai, and
M Amemiya, and
H Naganawa, and
T Sawa, and
M Ishizuka, and
T Takeuchi
November 1990,
The Journal of antibiotics,
H Kumagai, and
M Amemiya, and
H Naganawa, and
T Sawa, and
M Ishizuka, and
T Takeuchi
May 2009,
Applied and environmental microbiology,
H Kumagai, and
M Amemiya, and
H Naganawa, and
T Sawa, and
M Ishizuka, and
T Takeuchi
January 1989,
Journal of natural products,
H Kumagai, and
M Amemiya, and
H Naganawa, and
T Sawa, and
M Ishizuka, and
T Takeuchi
August 2002,
Science (New York, N.Y.),
H Kumagai, and
M Amemiya, and
H Naganawa, and
T Sawa, and
M Ishizuka, and
T Takeuchi
January 1985,
Biochemistry,
H Kumagai, and
M Amemiya, and
H Naganawa, and
T Sawa, and
M Ishizuka, and
T Takeuchi
March 1998,
The Journal of antibiotics,
H Kumagai, and
M Amemiya, and
H Naganawa, and
T Sawa, and
M Ishizuka, and
T Takeuchi
April 1983,
The Journal of antibiotics,
H Kumagai, and
M Amemiya, and
H Naganawa, and
T Sawa, and
M Ishizuka, and
T Takeuchi
September 1979,
Biochemistry,
H Kumagai, and
M Amemiya, and
H Naganawa, and
T Sawa, and
M Ishizuka, and
T Takeuchi
January 2022,
Frontiers in bioengineering and biotechnology,
