Long term follow-up results of high-dose rate remote afterloading intracavitary radiation therapy for carcinoma of the uterine cervix. 1994

M Chatani, and Y Matayoshi, and N Masaki, and T Teshima, and T Inoue
Department of Radiation Therapy, Center for Adult Diseases, Osaka.

OBJECTIVE High-dose rate remote afterloading intracavitary radiation therapy (HDR) has been used as more safety system by the dose calculation using computer system before treatment and dose monitoring system using semiconductor dosimeter (ICD-5). This study shows our long-term follow-up results concerning survival, prognostic factor and late complications. METHODS Between August 1978 and December 1982, a total of 200 patients with carcinoma of the intact uterine cervix were treated using HDR. According to the staging system of UICC (1987), 8 patients were classified into Stage Ia, 22 Ib, 22 IIa, 53 IIb, 85 III, and 10 IV. RESULTS Cause specific five- and ten-year survival rates by Stage were 100%, 100% in Stage Ia, 90%, 90% in Stage Ib, 76%, 76% in Stage IIa, 86%, 84% in Stage IIb, 54%, 46% in Stage III and 20%, 20% in Stage IV, respectively. Significant prognostic factors by Cox's multivariate analysis were stage (p = 0.0001), the value of hemoglobin (p = 0.0005) and older age (p = 0.0114). Concerning stage classification the value of hemoglobin was the most important prognostic factor in Stage II (p = 0.032) and Stage III (p = 0.0015). Late complications requiring medical treatment after RALS developed in 24 patients (12%), i.e., rectum 14 (7), bladder 8 (4), small intestine 5 (3), sigmoid colon 1 (1). Severe complications requiring surgery were noted in 9 patients (5%). CONCLUSIONS HDR yields good results of survival with a low risk of severe side effects for the treatment of carcinoma of uterine cervix based on our long-term follow-up results.

UI MeSH Term Description Entries
D007564 Japan A country in eastern Asia, island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. The capital is Tokyo. Bonin Islands
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009367 Neoplasm Staging Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011879 Radiotherapy Dosage The total amount of radiation absorbed by tissues as a result of radiotherapy. Dosage, Radiotherapy,Dosages, Radiotherapy,Radiotherapy Dosages
D001918 Brachytherapy A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues. Curietherapy,Implant Radiotherapy,Plaque Therapy, Radioisotope,Radioisotope Brachytherapy,Radiotherapy, Interstitial,Radiotherapy, Intracavity,Radiotherapy, Surface,Brachytherapy, Radioisotope,Interstitial Radiotherapy,Intracavity Radiotherapy,Radioisotope Plaque Therapy,Radiotherapy, Implant,Surface Radiotherapy,Therapy, Radioisotope Plaque
D002277 Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer." Carcinoma, Anaplastic,Carcinoma, Spindle-Cell,Carcinoma, Undifferentiated,Carcinomatosis,Epithelial Neoplasms, Malignant,Epithelioma,Epithelial Tumors, Malignant,Malignant Epithelial Neoplasms,Neoplasms, Malignant Epithelial,Anaplastic Carcinoma,Anaplastic Carcinomas,Carcinoma, Spindle Cell,Carcinomas,Carcinomatoses,Epithelial Neoplasm, Malignant,Epithelial Tumor, Malignant,Epitheliomas,Malignant Epithelial Neoplasm,Malignant Epithelial Tumor,Malignant Epithelial Tumors,Neoplasm, Malignant Epithelial,Spindle-Cell Carcinoma,Spindle-Cell Carcinomas,Tumor, Malignant Epithelial,Undifferentiated Carcinoma,Undifferentiated Carcinomas
D002423 Cause of Death Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint. Causes of Death,Death Cause,Death Causes
D002583 Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX. Cancer of Cervix,Cancer of the Cervix,Cancer of the Uterine Cervix,Cervical Cancer,Cervical Neoplasms,Cervix Cancer,Cervix Neoplasms,Neoplasms, Cervical,Neoplasms, Cervix,Uterine Cervical Cancer,Cancer, Cervical,Cancer, Cervix,Cancer, Uterine Cervical,Cervical Cancer, Uterine,Cervical Cancers,Cervical Neoplasm,Cervical Neoplasm, Uterine,Cervix Neoplasm,Neoplasm, Cervix,Neoplasm, Uterine Cervical,Uterine Cervical Cancers,Uterine Cervical Neoplasm
D005260 Female Females

Related Publications

M Chatani, and Y Matayoshi, and N Masaki, and T Teshima, and T Inoue
November 1988, Rinsho hoshasen. Clinical radiography,
M Chatani, and Y Matayoshi, and N Masaki, and T Teshima, and T Inoue
January 1992, Cancer,
M Chatani, and Y Matayoshi, and N Masaki, and T Teshima, and T Inoue
May 1991, International journal of radiation oncology, biology, physics,
M Chatani, and Y Matayoshi, and N Masaki, and T Teshima, and T Inoue
December 1987, Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
M Chatani, and Y Matayoshi, and N Masaki, and T Teshima, and T Inoue
January 2005, Cancer,
M Chatani, and Y Matayoshi, and N Masaki, and T Teshima, and T Inoue
June 1985, Strahlentherapie,
M Chatani, and Y Matayoshi, and N Masaki, and T Teshima, and T Inoue
January 1992, Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
M Chatani, and Y Matayoshi, and N Masaki, and T Teshima, and T Inoue
October 1994, Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
M Chatani, and Y Matayoshi, and N Masaki, and T Teshima, and T Inoue
May 2002, Zhonghua zhong liu za zhi [Chinese journal of oncology],
Copied contents to your clipboard!