Biomaterial Database

[Influence of the conservative cholelitholytic therapy using chenodesoxycholic acid (CDC) on cholesterol and triglycerides in the blood of patients with gall stones]. 1975

W F Caspary, and R Kattermann

In 11 patients with radiolucent gallstones treated for 3-18 months with chenodeoxycholic acid (CDC) serum cholesterol and triglyceride levels were measured. No significant changes of serum cholesterol and triglycerides could be observed during the course of longterm treatment with CDC. After 3 and 6 months a not significant decrease of serum triglycerides (20.8% and 26.4% respectively) compared to pretreatment values was observed. Since hypercholesterolemia had been suggested to occur as a hazardous side-effect of CDC-treatment the results in accord with cholesterol pool size measurements suggest that long-term treatment with CDC does not result in hypercholesterolemia and an increased cholesterol pool-size.

UI	MeSH Term	Description	Entries
D008134	Long-Term Care	Care over an extended period, usually for a chronic condition or disability, requiring periodic, intermittent, or continuous care.	Care, Long-Term,Long Term Care
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D002635	Chenodeoxycholic Acid	A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.	Chenic Acid,Chenodeoxycholate,Chenodiol,Gallodesoxycholic Acid,Chenique Acid,Chenix,Chenofalk,Chenophalk,Henohol,Quenobilan,Quenocol,Sodium Chenodeoxycholate,Acid, Chenic,Acid, Chenique,Acid, Chenodeoxycholic,Acid, Gallodesoxycholic,Chenodeoxycholate, Sodium
D002769	Cholelithiasis	Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).	Gallstone Disease,Cholelithiases,Gallstone Diseases
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014280	Triglycerides	An ester formed from GLYCEROL and three fatty acid groups.	Triacylglycerol,Triacylglycerols,Triglyceride