BIOMAT Database Logo BIOMAT Database Logo

1,3-Diarylindan-2-carboxylic acids, potent and selective non-peptide endothelin receptor antagonists. 1994

J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
Research and Development Division, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.

UI MeSH Term Description Entries
D007189 Indans Aryl CYCLOPENTANES that are a reduced (protonated) form of INDENES. Indanones
D008958 Models, Molecular Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures. Molecular Models,Model, Molecular,Molecular Model
D008968 Molecular Conformation The characteristic three-dimensional shape of a molecule. Molecular Configuration,3D Molecular Structure,Configuration, Molecular,Molecular Structure, Three Dimensional,Three Dimensional Molecular Structure,3D Molecular Structures,Configurations, Molecular,Conformation, Molecular,Conformations, Molecular,Molecular Configurations,Molecular Conformations,Molecular Structure, 3D,Molecular Structures, 3D,Structure, 3D Molecular,Structures, 3D Molecular
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016232 Endothelins 21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides. Endothelium-Derived Vasoconstrictor Factors,Endothelin,Vasoconstrictor Factors, Endothelium-Derived
D017466 Receptors, Endothelin Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells. Endothelin Receptors,Receptors, Endothelium-Derived Vasoconstrictor Factor,Endothelin Receptor,Endothelium Derived Vasoconstrictor Factor Receptors,Receptors, Endothelins,Receptor, Endothelin,Receptors, Endothelium Derived Vasoconstrictor Factor
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
1,3-Disubstituted-2-carboxy quinolones: highly potent and selective endothelin A receptor antagonists.
July 2000, Bioorganic & medicinal chemistry letters,
J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722.
March 1996, Journal of medicinal chemistry,
J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists.
January 1997, Journal of medicinal chemistry,
J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ET(A) antagonists.
November 2001, Journal of medicinal chemistry,
J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546).
August 1998, Journal of medicinal chemistry,
J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists.
September 1992, Journal of medicinal chemistry,
J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
Potent non-peptide thrombin receptor antagonists.
March 2003, Current medicinal chemistry. Cardiovascular and hematological agents,
J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
N-Benzylindole-2-carboxylic acids: potent functional antagonists of the CCR2b chemokine receptor.
January 2004, Bioorganic & medicinal chemistry letters,
J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
New spiropiperidines as potent and selective non-peptide tachykinin NK2 receptor antagonists.
September 1995, Journal of medicinal chemistry,
J D Elliott, and M A Lago, and R D Cousins, and A Gao, and J D Leber, and K F Erhard, and P Nambi, and N A Elshourbagy, and C Kumar, and J A Lee
Carbazolothiophene-2-carboxylic acid derivatives as endothelin receptor antagonists.
March 2004, Bioorganic & medicinal chemistry letters,
Copied contents to your clipboard!