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We examined the expression of two well-characterized oncofetal antigens, the tumor associated glycoprotein-72 (TAG-72) and carcinoembryonic antigen (CEA), in malignant prostatic tissues. Three specific monoclonal antibodies, B72.3, CC49 and CC83, were used to examine the expression of TAG-72. Immunoreactivity was detected in 63% of the malignant specimens using B72.3. CC49 and CC83 were more sensitive than B72.3 in detecting TAG-72 expression. Immunoreactivity was detected in approximately 80% of prostatic adenocarcinomas with CC49 or CC83. The pattern and localization of TAG-72 immunoreactivity were similar for the three antibodies with most immunoreactivity observed within the cytoplasm of malignant cells and within the lumens of malignant glands. TAG-72 immunoreactivity was not detected within benign epithelium or stroma, with the exception of focal epithelial expression in areas of acute prostatitis. The COL-1 antibody to CEA did not detect CEA in benign glands, stroma, or malignant cells of prostate specimens resected for prostatic adenocarcinoma. These results demonstrate that TAG-72, but not CEA, is frequently expressed in prostatic adenocarcinomas.
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R F Meredith, and
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A F LoBuglio, and
A J Bueschen, and
R H Wheeler, and
C R Stockard, and
W E Grizzle
January 2001,
Oncology reports,
R B Myers, and
R F Meredith, and
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A J Bueschen, and
R H Wheeler, and
C R Stockard, and
W E Grizzle
April 1995,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
R B Myers, and
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A F LoBuglio, and
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R H Wheeler, and
C R Stockard, and
W E Grizzle
January 1991,
The International journal of biological markers,
R B Myers, and
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A F LoBuglio, and
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R H Wheeler, and
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W E Grizzle
November 1986,
International journal of cancer,
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April 1993,
The Journal of clinical endocrinology and metabolism,
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January 1990,
The Journal of nuclear medicine and allied sciences,
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May 1989,
International journal of cancer,
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Pathology oncology research : POR,
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December 2000,
International journal of cancer,
R B Myers, and
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W E Grizzle
January 1992,
Bulletin du cancer,
