BIOMAT Database Logo BIOMAT Database Logo

[CSF-1 (colony stimulating factors 1) and CSF-1 receptor. General review and expression in invasive breast tumors]. 1993

F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
Laboratoire d'anatomopathologie, hôpital Sainte-Anne, Paris, France.

CSF-1 (colony stimulating factor-1), initially considered to be a monocyte specific growth and differentiation factor [4], has recently been shown to be produced in human endometrium [16], placenta [7], as well as in numerous solid tumors [19-23, 26, 27]. The CSF-1 receptor (a protein product of c-fms) [24] is a member of the tyrosine kinase receptor family and an autocrine or paracrine mechanism of activation has been suggested. Overactivation of this receptor can lead to a malignant phenotype in various cell systems [20, 21]. We review the biology of CSF-1 and fms expression in normal as well as in malignant tissues with particular reference to a potential role for CSF-1 in breast tumour invasion.

UI MeSH Term Description Entries
D009361 Neoplasm Invasiveness Ability of neoplasms to infiltrate and actively destroy surrounding tissue. Invasiveness, Neoplasm,Neoplasm Invasion,Invasion, Neoplasm
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D003115 Colony-Stimulating Factors Glycoproteins found in a subfraction of normal mammalian plasma and urine. They stimulate the proliferation of bone marrow cells in agar cultures and the formation of colonies of granulocytes and/or macrophages. The factors include INTERLEUKIN-3; (IL-3); GRANULOCYTE COLONY-STIMULATING FACTOR; (G-CSF); MACROPHAGE COLONY-STIMULATING FACTOR; (M-CSF); and GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; (GM-CSF). MGI-1,Macrophage-Granulocyte Inducer,Colony Stimulating Factor,Colony-Stimulating Factor,MGI-1 Protein,Myeloid Cell-Growth Inducer,Protein Inducer MGI,Cell-Growth Inducer, Myeloid,Colony Stimulating Factors,Inducer, Macrophage-Granulocyte,Inducer, Myeloid Cell-Growth,MGI 1 Protein,MGI, Protein Inducer,Macrophage Granulocyte Inducer,Myeloid Cell Growth Inducer
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000230 Adenocarcinoma A malignant epithelial tumor with a glandular organization. Adenocarcinoma, Basal Cell,Adenocarcinoma, Granular Cell,Adenocarcinoma, Oxyphilic,Adenocarcinoma, Tubular,Adenoma, Malignant,Carcinoma, Cribriform,Carcinoma, Granular Cell,Carcinoma, Tubular,Adenocarcinomas,Adenocarcinomas, Basal Cell,Adenocarcinomas, Granular Cell,Adenocarcinomas, Oxyphilic,Adenocarcinomas, Tubular,Adenomas, Malignant,Basal Cell Adenocarcinoma,Basal Cell Adenocarcinomas,Carcinomas, Cribriform,Carcinomas, Granular Cell,Carcinomas, Tubular,Cribriform Carcinoma,Cribriform Carcinomas,Granular Cell Adenocarcinoma,Granular Cell Adenocarcinomas,Granular Cell Carcinoma,Granular Cell Carcinomas,Malignant Adenoma,Malignant Adenomas,Oxyphilic Adenocarcinoma,Oxyphilic Adenocarcinomas,Tubular Adenocarcinoma,Tubular Adenocarcinomas,Tubular Carcinoma,Tubular Carcinomas
D016184 Receptors, Colony-Stimulating Factor Cell surface receptors for colony stimulating factors, local mediators, and hormones that regulate the survival, proliferation, and differentiation of hemopoietic cells. Colony-Stimulating Factor Receptors,Hematopoietic Growth Factors Receptors,Receptors, Hematopoietic Growth Factors,CSF Receptors,Colony-Stimulating Factor Receptor,Hematopoietic Growth Factor Receptor,Colony Stimulating Factor Receptor,Colony Stimulating Factor Receptors,Receptor, Colony-Stimulating Factor,Receptors, CSF,Receptors, Colony Stimulating Factor

Related Publications

F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
[Expression of CSF-1 (colony stimulating factor) and its receptor (c-fms) in breast tumors].
January 1993, Pathologie-biologie,
F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34.
December 2012, Cytokine,
F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
Expression of colony stimulating factor-1 receptor (CSF-1R) by CNS neurons in mice.
September 1999, Journal of neuroscience research,
F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
Role of the colony-stimulating factor (CSF)/CSF-1 receptor axis in cancer.
April 2016, Biochemical Society transactions,
F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
Colony stimulating factors (CSF) biosimilars. Progress?
March 2012, Targeted oncology,
F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
Mouse mesangial cells produce colony-stimulating factor-1 (CSF-1) and express the CSF-1 receptor.
June 1990, Journal of immunology (Baltimore, Md. : 1950),
F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
[Colony stimulating factors in polychemotherapy of testicular tumors. A comparison between G-CSF and GM-CSF].
May 1999, Der Urologe. Ausg. A,
F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
Granulocyte-colony stimulating factor (G-CSF) and G-CSF receptor expression in human ischemic stroke.
January 2007, Acta neuropathologica,
F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling.
February 2012, Blood,
F Beuvon, and C Palud, and R Tang, and A de la Rochefordière, and S Kheirallah, and P Pouillart, and S M Scholl
Human colony-stimulating factor (CSF-1) radioimmunoassay: resolution of three subclasses of human colony-stimulating factors.
September 1981, Blood,
Copied contents to your clipboard!