BIOMAT Database Logo BIOMAT Database Logo

Expression of insulin-like growth factor II by a gastric carcinoma associated with hypoglycaemia. 1994

T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Third Department of Medicine, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan.

A gastric cancer with liver metastases was associated with low morning levels of plasma glucose (24 mg/dl), insulin (< 2.5 microU/ml) and growth hormone (0.23 ng/ml). Primary and metastatic tumour tissue stained positively with anti-insulin-like growth factor II (IGF-II) monoclonal antibody. Western immunoblot analysis revealed a high molecular weight IGF-II in the serum: 15 kDa (normal: 7.5 kDa). Postmortem reverse transcription polymerase chain reaction on mRNA from both sites revealed 471 base pairs size cDNA encoding prepro-IGF-II. These results suggest that the gastric carcinoma encoded, expressed, and secreted IGF-II, probably causing the extrapancreatic tumour hypoglycaemia.

UI MeSH Term Description Entries
D007003 Hypoglycemia A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH. Fasting Hypoglycemia,Postabsorptive Hypoglycemia,Postprandial Hypoglycemia,Reactive Hypoglycemia,Hypoglycemia, Fasting,Hypoglycemia, Postabsorptive,Hypoglycemia, Postprandial,Hypoglycemia, Reactive
D007335 Insulin-Like Growth Factor II A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults. IGF-II,Multiplication-Stimulating Activity,Somatomedin MSA,IGF-2,Insulin Like Growth Factor II,Insulin-Like Somatomedin Peptide II,Multiplication-Stimulating Factor,Somatomedin A,Factor, Multiplication-Stimulating,Insulin Like Somatomedin Peptide II,Multiplication Stimulating Activity,Multiplication Stimulating Factor
D008113 Liver Neoplasms Tumors or cancer of the LIVER. Cancer of Liver,Hepatic Cancer,Liver Cancer,Cancer of the Liver,Cancer, Hepatocellular,Hepatic Neoplasms,Hepatocellular Cancer,Neoplasms, Hepatic,Neoplasms, Liver,Cancer, Hepatic,Cancer, Liver,Cancers, Hepatic,Cancers, Hepatocellular,Cancers, Liver,Hepatic Cancers,Hepatic Neoplasm,Hepatocellular Cancers,Liver Cancers,Liver Neoplasm,Neoplasm, Hepatic,Neoplasm, Liver
D008297 Male Males
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D013274 Stomach Neoplasms Tumors or cancer of the STOMACH. Cancer of Stomach,Gastric Cancer,Gastric Neoplasms,Stomach Cancer,Cancer of the Stomach,Gastric Cancer, Familial Diffuse,Neoplasms, Gastric,Neoplasms, Stomach,Cancer, Gastric,Cancer, Stomach,Cancers, Gastric,Cancers, Stomach,Gastric Cancers,Gastric Neoplasm,Neoplasm, Gastric,Neoplasm, Stomach,Stomach Cancers,Stomach Neoplasm

Related Publications

T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Hypoglycaemia associated with the production of insulin-like growth factor II and insulin-like growth factor binding protein 6 by a haemangiopericytoma.
August 1999, Clinical endocrinology,
T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Case report: Insulin-like growth factor II expression in hepatocellular carcinoma with alcoholic liver fibrosis accompanied by hypoglycaemia.
January 1998, Journal of gastroenterology and hepatology,
T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Tumour suppression associated with expression of human insulin-like growth factor II.
May 1991, British journal of cancer,
T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Big insulin-like growth factor II-producing hepatocellular carcinoma associated with hypoglycemia.
December 1995, Internal medicine (Tokyo, Japan),
T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Expression of insulin-like growth factor II mRNA in hepatocellular carcinoma.
February 1998, Journal of gastroenterology and hepatology,
T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Insulin-like growth factor 1 in patients with hypoglycaemia.
March 1990, Annals of clinical biochemistry,
T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Severe hypoglycaemia caused by raised insulin-like growth factor II in disseminated breast cancer.
October 1999, Journal of clinical pathology,
T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Gastric neuroendocrine carcinoma with non-islet cell tumor hypoglycemia associated with enhanced production of insulin-like growth factor II.
January 2013, Internal medicine (Tokyo, Japan),
T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Expression of a type I insulin-like growth factor receptor with low affinity for insulin-like growth factor II.
January 1992, The Biochemical journal,
T Horiuchi, and Y Shinohara, and Y Sakamoto, and N Hizuka, and T Watabe, and O Mokuda, and K Tanaka, and N Shimizu, and I Sugano, and K Nagao
Hypoglycaemia caused by secretion of insulin-like growth factor 2 in a primary renal cell carcinoma.
January 2001, Clinical oncology (Royal College of Radiologists (Great Britain)),
Copied contents to your clipboard!