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Hepatic microsomal coumarin 7-hydroxylase activity has been determined in male and female mice of strains A/J, AKR, BALB/c, CBA/Ca, C3H/He, C57BL/6J, DBA/2 and 129. In males, coumarin 7-hydroxylase activity was highest in liver microsomes from DBA/2 mice and lowest in BALB/c mice. With female mice enzyme activity was highest in DBA/2 and 129 strains, intermediate in the CBA/Ca strain and comparatively low in the other five strains. Marked sex differences were observed in coumarin 7-hydroxylase activity with enzyme activity in female animals from strains DBA/2, 129 and CBA/Ca being 4.8-, 6.2- and 4.8-fold higher, respectively, than in male mice. In contrast, only minor sex and strain differences in levels of total microsomal cytochrome P-450 were observed. These results demonstrate marked sex and strain differences in mouse hepatic microsomal coumarin 7-hydroxylase activity. Such differences may be due to variations in particular cytochrome P-450 isoenzymes such as CYP2A5, not all of which can be explained by the known allelic difference in the Cyp2a-5 locus.
M van Iersel, and
D G Walters, and
R J Price, and
D P Lovell, and
B G Lake
December 1988,
Archives of biochemistry and biophysics,
M van Iersel, and
D G Walters, and
R J Price, and
D P Lovell, and
B G Lake
May 1990,
Biochemical pharmacology,
M van Iersel, and
D G Walters, and
R J Price, and
D P Lovell, and
B G Lake
January 1985,
Drug metabolism and disposition: the biological fate of chemicals,
M van Iersel, and
D G Walters, and
R J Price, and
D P Lovell, and
B G Lake
October 1988,
Biochemical pharmacology,
M van Iersel, and
D G Walters, and
R J Price, and
D P Lovell, and
B G Lake
November 1984,
European journal of biochemistry,
M van Iersel, and
D G Walters, and
R J Price, and
D P Lovell, and
B G Lake
March 1993,
Biochemical pharmacology,
M van Iersel, and
D G Walters, and
R J Price, and
D P Lovell, and
B G Lake
October 1971,
Biochemical pharmacology,
M van Iersel, and
D G Walters, and
R J Price, and
D P Lovell, and
B G Lake
August 1989,
Pharmacology & toxicology,
M van Iersel, and
D G Walters, and
R J Price, and
D P Lovell, and
B G Lake
October 1993,
Naunyn-Schmiedeberg's archives of pharmacology,
M van Iersel, and
D G Walters, and
R J Price, and
D P Lovell, and
B G Lake
December 1989,
Gastroenterology,
