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A double-blind study of the effect of two inhibitors of prostaglandin synthesis on the TRH stimulation of serum TSH and prolactin was carried out in 35 normal males. The subjects were evaluated before and after the administration of indomethacin or aspirin for one week. Both indomethacin and aspirin lowered plasma prostaglandin E and F levels significantly. Indomethacin treatment had no effect on the serum TSH or prolactin response to 100 mug TRH or the serum T3 and T4 levels. In contrast, aspirin treatment significantly decreased the serum TSH response to TRH and significantly lowered mean total serum T3 (RIA) and T4 (D). There was no effect on the prolactin response to TRH. These findings suggest that aspirin blocks TRH responsiveness by a mechanism other than the inhibition of prostaglandin synthesis, probably by its previously demonstrated effect on increasing the fraction of unbound thyroid hormone.
J N Ramey, and
G N Burrow, and
S W Spaulding, and
R K Donabedian, and
L Speroff, and
A G Frantz
August 1988,
British journal of clinical pharmacology,
J N Ramey, and
G N Burrow, and
S W Spaulding, and
R K Donabedian, and
L Speroff, and
A G Frantz
January 1972,
Clinical pharmacology and therapeutics,
J N Ramey, and
G N Burrow, and
S W Spaulding, and
R K Donabedian, and
L Speroff, and
A G Frantz
January 1989,
Minerva endocrinologica,
J N Ramey, and
G N Burrow, and
S W Spaulding, and
R K Donabedian, and
L Speroff, and
A G Frantz
December 1978,
Journal of pharmacokinetics and biopharmaceutics,
J N Ramey, and
G N Burrow, and
S W Spaulding, and
R K Donabedian, and
L Speroff, and
A G Frantz
February 1975,
European journal of clinical pharmacology,
J N Ramey, and
G N Burrow, and
S W Spaulding, and
R K Donabedian, and
L Speroff, and
A G Frantz
May 1986,
Clinical science (London, England : 1979),
J N Ramey, and
G N Burrow, and
S W Spaulding, and
R K Donabedian, and
L Speroff, and
A G Frantz
November 1956,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J N Ramey, and
G N Burrow, and
S W Spaulding, and
R K Donabedian, and
L Speroff, and
A G Frantz
January 1973,
Arkhiv patologii,
J N Ramey, and
G N Burrow, and
S W Spaulding, and
R K Donabedian, and
L Speroff, and
A G Frantz
April 1998,
Journal of endocrinological investigation,
J N Ramey, and
G N Burrow, and
S W Spaulding, and
R K Donabedian, and
L Speroff, and
A G Frantz
July 1987,
Clinical science (London, England : 1979),
