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In recent years new sensitive immunochemoluminiscentic methods to measure thyroid stimulating hormone, TSH have been introduced. In this investigation we have made a comparison between an older, less sensitive, second generation TSH assay and a new, sensitive, third generation TSH assay in order to evaluate if new information of clinical value is obtained. We found that 20% of all the sera that were sent to the laboratory for TSH measurement showed low values. In the sera with low TSH concentration a great variation was observed between the "correct" values found with the third generation assay and the values found with the less sensitive second generation assay. We conclude, that since many sera sent to a routine laboratory have low TSH concentrations, and since it is of clinical importance to know the correct TSH value in many different patient categories, a third generation TSH assay is recommended in the daily routine.
L H Thomsen, and
E Vittinghus, and
P Laurberg
May 1995,
Annals of clinical biochemistry,
L H Thomsen, and
E Vittinghus, and
P Laurberg
October 1993,
Clinical chemistry,
L H Thomsen, and
E Vittinghus, and
P Laurberg
January 1998,
The Journal of maternal-fetal medicine,
L H Thomsen, and
E Vittinghus, and
P Laurberg
January 2007,
Clinical chemistry and laboratory medicine,
L H Thomsen, and
E Vittinghus, and
P Laurberg
June 2003,
Nederlands tijdschrift voor geneeskunde,
L H Thomsen, and
E Vittinghus, and
P Laurberg
March 1995,
Nihon rinsho. Japanese journal of clinical medicine,
L H Thomsen, and
E Vittinghus, and
P Laurberg
December 1999,
Nihon rinsho. Japanese journal of clinical medicine,
L H Thomsen, and
E Vittinghus, and
P Laurberg
October 1972,
Horumon to rinsho. Clinical endocrinology,
L H Thomsen, and
E Vittinghus, and
P Laurberg
July 2010,
Nihon rinsho. Japanese journal of clinical medicine,
L H Thomsen, and
E Vittinghus, and
P Laurberg
August 2005,
Nihon rinsho. Japanese journal of clinical medicine,
