Biomaterial Database

Evaluation of scintigraphic and roentgenologic studies in Paget's disease under treatment. 1976

C J Vellenga, and E K Pauwels, and O L Bijvoet, and D J Hosking

Scintigraphic and roentgenological studies in 9 patients, treated for Paget's disease, were evaluated before and during treatment and related to the values of serum alkaline phosphatase. On the initial studies--before treatment--25 lesions were found on both scintigram and roentgenogram. One lesion--proven by biopsy--was only seen on the scintigram. The roentgenograms showed no changes during this period, ranging from 6-16 months, except for one lesion with dubious progression. The scintigrams, carried out using 99Tcm-EHDP, showed both a qualitative and quantitative improvement in 7 cases. The ratios of radionuclide accumulation in Pagetoid bone and normal bone corresponded well with the values of serum alkaline phosphatase. In 4 out of 9 cases, however, the scintigram still demonstrated pathologic uptake of radioactivity, while serum alkaline phosphatase levels had dropped to normal values. It is concluded that bone scintigraphy may be of value for the follow up of patients under treatment for Paget's disease.

UI	MeSH Term	Description	Entries
D010001	Osteitis Deformans	A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.	Paget's Disease of Bone,Osseous Paget's Disease,Paget Disease of Bone,Paget Disease, Bone,Pagets Disease, Bone
D011859	Radiography	Examination of any part of the body for diagnostic purposes by means of X-RAYS or GAMMA RAYS, recording the image on a sensitized surface (such as photographic film).	Radiology, Diagnostic X-Ray,Roentgenography,X-Ray, Diagnostic,Diagnostic X-Ray,Diagnostic X-Ray Radiology,X-Ray Radiology, Diagnostic,Diagnostic X Ray,Diagnostic X Ray Radiology,Diagnostic X-Rays,Radiology, Diagnostic X Ray,X Ray Radiology, Diagnostic,X Ray, Diagnostic,X-Rays, Diagnostic
D011877	Radionuclide Imaging	The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.	Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D005069	Evaluation Studies as Topic	Works about studies that determine the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies.	Critique,Evaluation Indexes,Evaluation Methodology,Evaluation Report,Evaluation Research,Methodology, Evaluation,Pre-Post Tests,Qualitative Evaluation,Quantitative Evaluation,Theoretical Effectiveness,Use-Effectiveness,Critiques,Effectiveness, Theoretical,Evaluation Methodologies,Evaluation Reports,Evaluation, Qualitative,Evaluation, Quantitative,Evaluations, Qualitative,Evaluations, Quantitative,Indexes, Evaluation,Methodologies, Evaluation,Pre Post Tests,Pre-Post Test,Qualitative Evaluations,Quantitative Evaluations,Report, Evaluation,Reports, Evaluation,Research, Evaluation,Test, Pre-Post,Tests, Pre-Post,Use Effectiveness
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000469	Alkaline Phosphatase	An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
D012968	Etidronic Acid	A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.	EHDP,Ethanehydroxydiphosphonate,Etidronate,Etidronate Disodium,Sodium Etidronate,(1-hydroxyethylene)diphosphonic acid,(1-hydroxyethylene)diphosphonic acid, Tetrapotassium Salt,1,1-hydroxyethylenediphosphonate,1-Hydroxyethane-1,1-Diphosphonate,1-Hydroxyethylidene-1,1-Bisphosphonate,Dicalcium EHDP,Dicalcium Etidronate,Didronel,Disodium 1-Hydroxyethylene Diphosphonate,Disodium Etidronate,Ethanehydroxyphosphate,Etidronate, Tetrapotassium Salt,HEDP,HEDSPA,Hydroxyethanediphosphonate,Hydroxyethylidene Diphosphonic Acid,Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt,Xidifon,Xidiphon,Xydiphone,1 Hydroxyethane 1,1 Diphosphonate,1 Hydroxyethylidene 1,1 Bisphosphonate,1,1 hydroxyethylenediphosphonate,1-Hydroxyethylene Diphosphonate, Disodium,Diphosphonate, Disodium 1-Hydroxyethylene,Diphosphonic Acid, Hydroxyethylidene,Disodium 1 Hydroxyethylene Diphosphonate,EHDP, Dicalcium,Etidronate, Dicalcium,Etidronate, Disodium,Etidronate, Sodium,Salt Etidronate, Tetrapotassium,Tetrapotassium Salt Etidronate
D013667	Technetium	The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m	Technetium 99m,99m, Technetium