Biomaterial Database

[The serine- and threonine dehydratases of brucellae]. 1976

V A Shirokov, and S P Merinov

In studying 62 strains of brucellae of all the known species an inductive enzyme--1-serine-hydrolyase(desaminating) was revealed in the intact cells and cell-free extracts. The activity of this enzyme depended on the species of brucellae and showed a sharp elevation in destruction of the cells with supersonic waves. Intact brucellae failed to desaminate treonine. A constitution enzyme 1-treonine-hydrolase (desaminating) was found in the cell-free extracts of Br. neotomae and brucellae isolated from murine rodents of the Northern Caucasus. Some properties of both enzymes were studied.

UI	MeSH Term	Description	Entries
D002002	Brucella	A genus of gram-negative, aerobic bacteria that causes BRUCELLOSIS. Its cells are nonmotile coccobacilli and are animal parasites and pathogens. The bacterium is transmissible to humans through contact with infected dairy products or tissue.
D002003	Brucella abortus	A species of the genus BRUCELLA whose natural hosts are cattle and other bovidae. Abortion and placentitis are frequently produced in the pregnant animal. Other mammals, including humans, may be infected.	Bacterium abortus,Brucella melitensis biovar abortus
D002384	Catalysis	The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.	Catalyses
D006836	Hydro-Lyases	Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.	Dehydratase,Dehydratases,Hydrase,Hydrases,Hydro Lyase,Hydro-Lyase,Hydro Lyases,Lyase, Hydro,Lyases, Hydro
D000641	Ammonia	A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
D012694	Serine	A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.	L-Serine,L Serine
D012695	L-Serine Dehydratase	A PYRIDOXAL-phosphate containing enzyme that catalyzes the dehydration and deamination of L-serine to form pyruvate. This enzyme was formerly listed as EC 4.2.1.13.	Serine Deaminase,Serine Dehydratase,L-Serine Ammonia-Lyase,Serine-Threonine Dehydratase,Ammonia-Lyase, L-Serine,Deaminase, Serine,Dehydratase, L-Serine,Dehydratase, Serine,Dehydratase, Serine-Threonine,L Serine Ammonia Lyase,L Serine Dehydratase,Serine Threonine Dehydratase
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species
D013912	Threonine	An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.	L-Threonine,L Threonine
D013913	Threonine Dehydratase	A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16.	Threonine Deaminase,Threonine Dehydrase,Threonine Ammonia-Lyase,Ammonia-Lyase, Threonine,Deaminase, Threonine,Dehydrase, Threonine,Dehydratase, Threonine,Threonine Ammonia Lyase