BIOMAT Database Logo BIOMAT Database Logo

A 5-lipoxygenase inhibitor, FR110302, inhibits ozone-induced airway hyperresponsiveness in guinea pigs and dogs. 1993

M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Tsukuba Research Laboratories, Ibaraki, Japan.

Airway hyperresponsiveness is a key feature of asthma, and attenuating airway hyperresponsiveness is an important part of asthma therapy. In the present study we examined the inhibitory effect of a potent 5-lipoxygenase inhibitor, FR110302, on airway hyperresponsiveness induced by ozone exposure in guinea pigs and dogs. Respiratory resistance (Rrs) was measured by a forced oscillation method. Airway responsiveness was determined from the dose-response curve of Rrs to acetylcholine. Guinea pigs were exposed to 2.5 ppm ozone for 1 h. In a control group of guinea pigs, delta log PC100 (the index of the ozone-induced airway hyperresponsiveness) was 0.58 +/- 0.04 (log mg/ml). Treatment with FR110302 (10 or 100 mg/kg p.o.) significantly diminished delta log PC100 (10 mg/kg: 0.22 +/- 0.10; 100 mg/kg; 0.11 +/- 0.06). Dogs were exposed to 3 ppm ozone for 2 h. In a control group of dogs, delta log Dmin (another index of the ozone-induced airway hyperresponsiveness) was 1.24 +/- 0.15 (log unit). Treatment with FR110302 (1 or 3.2 mg/kg p.o.) significantly diminished delta log Dmin (1 mg/kg: 0.60 +/- 0.18; 3.2 mg/kg: 0.27 +/- 0.12). These results suggest that FR110302 may be a useful drug for attenuating airway hyperresponsiveness in asthmatic patients.

UI MeSH Term Description Entries
D009284 Naphthols Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications. Hydroxynaphthalene,Hydroxynaphthalenes,Naphthol
D010126 Ozone The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE). Ground Level Ozone,Low Level Ozone,Tropospheric Ozone,Level Ozone, Ground,Level Ozone, Low,Ozone, Ground Level,Ozone, Low Level,Ozone, Tropospheric
D011804 Quinolines
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000109 Acetylcholine A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. 2-(Acetyloxy)-N,N,N-trimethylethanaminium,Acetilcolina Cusi,Acetylcholine Bromide,Acetylcholine Chloride,Acetylcholine Fluoride,Acetylcholine Hydroxide,Acetylcholine Iodide,Acetylcholine L-Tartrate,Acetylcholine Perchlorate,Acetylcholine Picrate,Acetylcholine Picrate (1:1),Acetylcholine Sulfate (1:1),Bromoacetylcholine,Chloroacetylcholine,Miochol,Acetylcholine L Tartrate,Bromide, Acetylcholine,Cusi, Acetilcolina,Fluoride, Acetylcholine,Hydroxide, Acetylcholine,Iodide, Acetylcholine,L-Tartrate, Acetylcholine,Perchlorate, Acetylcholine
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000403 Airway Resistance Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow. Airway Resistances,Resistance, Airway,Resistances, Airway
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016535 Bronchial Hyperreactivity Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory. Bronchial Hyperreactivities,Hyperreactivities, Bronchial,Hyperreactivity, Bronchial

Related Publications

M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
Tazanolast inhibits ozone-induced airway hyperresponsiveness in guinea pigs.
May 1998, American journal of respiratory and critical care medicine,
M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
[Ozone-induced airway hyperresponsiveness in guinea pigs].
November 1989, Arerugi = [Allergy],
M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
BI-L-239, a 5-lipoxygenase inhibitor, blocks inhaled antigen-induced airway hyperresponsiveness in conscious guinea pigs.
September 1991, Agents and actions,
M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
Ozone-induced modulation of airway hyperresponsiveness in guinea pigs.
June 2002, Research report (Health Effects Institute),
M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
[The effect of a selective 5-lipoxygenase inhibitor, AA-861 on airway hyperresponsiveness induced by ozone exposure in dogs].
July 1989, Arerugi = [Allergy],
M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
Ambroxol inhibits airway hyperresponsiveness induced by ozone in dogs.
January 1989, Respiration; international review of thoracic diseases,
M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
PACAP reverses airway hyperresponsiveness induced by ozone exposure in guinea pigs.
January 1999, Respiration; international review of thoracic diseases,
M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
Antibody to interleukin-5 inhibits virus-induced airway hyperresponsiveness to histamine in guinea pigs.
January 1995, American journal of respiratory and critical care medicine,
M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
Dose-response relationship of ozone-induced airway hyperresponsiveness in unanesthetized guinea pigs.
June 1990, Journal of toxicology and environmental health,
M Asano, and T Imai, and H Inoue, and T Masunaga, and N Inamura, and T Yatabe, and J Hiroi, and K Nakahara, and Y Notsu, and T Takishima
Effect of ozone exposure on antigen-induced airway hyperresponsiveness in guinea pigs.
August 1994, Journal of toxicology and environmental health,
Copied contents to your clipboard!