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A pressure type syringe was used to give intraligamentary injections (IL) to upper teeth of two formulations commonly used in general practice, lignocaine and prilocaine. Assay of plasma levels of drug was carried out by high performance liquid chromatography. Results of assays after intraligamentary injections were then compared with results of assays after intravenous injections of plain drug in the same subjects. Both formulations of local anaesthetic were found as peak levels in the circulation, presumably after intraosseous spread, by 2 minutes following the intraligamentary injections. For lignocaine the peak amount was nearly 7% of the intravenous dose and for prilocaine the peak amount was 25% of the intravenous dose, at 2 minutes after injection. It was concluded that IL injections for healthy adults were unlikely to cause systemic unwanted effects when given in small doses.
H Cannell, and
C Kerawala, and
K Webster, and
R Whelpton
June 1988,
Dental update,
H Cannell, and
C Kerawala, and
K Webster, and
R Whelpton
March 2022,
British dental journal,
H Cannell, and
C Kerawala, and
K Webster, and
R Whelpton
January 1990,
Deutsche Zeitschrift fur Mund-, Kiefer- und Gesichts-Chirurgie,
H Cannell, and
C Kerawala, and
K Webster, and
R Whelpton
January 1991,
General dentistry,
H Cannell, and
C Kerawala, and
K Webster, and
R Whelpton
January 1985,
ZWR,
H Cannell, and
C Kerawala, and
K Webster, and
R Whelpton
November 2018,
Pediatric dentistry,
H Cannell, and
C Kerawala, and
K Webster, and
R Whelpton
July 1980,
Anesthesiology,
H Cannell, and
C Kerawala, and
K Webster, and
R Whelpton
July 2002,
International endodontic journal,
H Cannell, and
C Kerawala, and
K Webster, and
R Whelpton
December 1992,
Journal of dentistry,
H Cannell, and
C Kerawala, and
K Webster, and
R Whelpton
April 1985,
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