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Effect of recombinant human erythropoietin after allogenic bone marrow transplantation. 1993
H Link, and
T Brune, and
G Hübner, and
H Diedrich, and
M Freund, and
M Stoll, and
D Peest, and
W Ebell, and
C Bettoni, and
W Oster
Interdisciplinary Unit for Bone Marrow Transplantation, Medical School, Hannover, Germany.
The hematologic effects of recombinant human erythropoietin after allogeneic bone marrow transplantation (BMT) were studied. Nineteen patients received 150 U/kg/day of C127 mouse-cell-derived recombinant human erythropoietin (rHu EPO) as a daily continuous intravenous infusion until hematocrit exceeded 35%. These data were compared with a treatment-matched historical control group of 43 patients. RHu EPO-treated patients recovered erythropoiesis more rapidly and became independent from erythrocyte transfusions after a median of 17 days, which was 7 days earlier than the control patients.
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