-transparent.png){kind=logo}
Exposure of normal guinea pigs to an aerosol of PAF induced a selective increase in the percentage of eosinophils in bronchoalveolar lavage (BAL) fluid 24 h after challenge. Challenge of actively sensitised guinea pigs with an aerosol of ovalbumin also induced a selective increase in the percentage of eosinophils recovered in BAL fluid 24 h post challenge. Pretreatment of actively sensitised guinea pigs or normal guinea pigs with unfractionated heparin significantly reduced such eosinophil infiltration induced by allergen or PAF challenge respectively, although higher amounts of heparin were required to inhibit antigen induced eosinophil infiltration. Similar effects were also observed following treatment with the low molecular weight heparin-like material ORG 10172 but not the anionic molecule polyglutamic acid or high molecular weight dextrans. These results suggest that proteoglycans may possess anti-allergic activity that is not necessarily related to either such molecules being anionic in nature nor to anti-coagulant activity.
E A Seeds, and
J Hanss, and
C P Page
January 1995,
Pulmonary pharmacology,
E A Seeds, and
J Hanss, and
C P Page
January 1991,
Journal of lipid mediators,
E A Seeds, and
J Hanss, and
C P Page
January 1990,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
E A Seeds, and
J Hanss, and
C P Page
January 2001,
Pulmonary pharmacology & therapeutics,
E A Seeds, and
J Hanss, and
C P Page
December 1991,
Lipids,
E A Seeds, and
J Hanss, and
C P Page
March 1988,
European journal of pharmacology,
E A Seeds, and
J Hanss, and
C P Page
January 1997,
Pneumonologia i alergologia polska,
E A Seeds, and
J Hanss, and
C P Page
January 1988,
Allergy proceedings : the official journal of regional and state allergy societies,
E A Seeds, and
J Hanss, and
C P Page
June 1994,
Asian Pacific journal of allergy and immunology,
E A Seeds, and
J Hanss, and
C P Page
September 1992,
Agents and actions,
