-transparent.png){kind=logo}
Phenylpropanolamine (PPA) is thought to inhibit feeding by activation of alpha 1-adrenergic receptors within the paraventricular hypothalamus (PVN). Systemic injections of the PPA component enantiomers, d- and l-norephedrine (NEP), result in differential suppression of feeding (l-NEP more potent than d-NEP). Whether the norephedrine racemates induce differential anorexia subsequent to injection into the PVN is unknown. In the present study, adult male rats received intra-PVN injections of the d- and l-norephedrine enantiomers (0, 80, 160, and 240 nmol). Significantly greater anorexia was obtained for l-NEP relative to d-NEP. These results document a stereospecific effect of the norephedrine enantiomers within the PVN in inhibiting food intake and suggest that the interaction of these enantiomers with PVN alpha 1-adrenoceptors may mediate the similar difference in potency noted for systemic injections of d- and l-norephedrine.
P J Wellman, and
B DiCarlo, and
A Morien, and
B T Davies
February 1990,
Pharmacology, biochemistry, and behavior,
P J Wellman, and
B DiCarlo, and
A Morien, and
B T Davies
September 1974,
Research communications in chemical pathology and pharmacology,
P J Wellman, and
B DiCarlo, and
A Morien, and
B T Davies
October 1983,
Physiology & behavior,
P J Wellman, and
B DiCarlo, and
A Morien, and
B T Davies
November 1997,
Pharmacology, biochemistry, and behavior,
P J Wellman, and
B DiCarlo, and
A Morien, and
B T Davies
September 1973,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
P J Wellman, and
B DiCarlo, and
A Morien, and
B T Davies
September 1978,
Physiology & behavior,
P J Wellman, and
B DiCarlo, and
A Morien, and
B T Davies
December 1999,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
P J Wellman, and
B DiCarlo, and
A Morien, and
B T Davies
October 2016,
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association,
P J Wellman, and
B DiCarlo, and
A Morien, and
B T Davies
January 1989,
Biochemical pharmacology,
P J Wellman, and
B DiCarlo, and
A Morien, and
B T Davies
March 1976,
British journal of pharmacology,
