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Normally cycling Rhesus monkeys were treated with diethylstilbestrol (25 mg/day) alone or in combination with indomethacin (25 mg/day) for five consecutive days beginning in the early luteal and mid-luteal phase of the menstrual cycle. Blood specimens were obtained daily to monitor corpus luteum function (progesterone), and the length of each menstrual cycle was recorded. Diethylstilbestrol alone cause premature luteolysis as indicated by decreasing plasma progesterone and shortened menstrual cycle, and indomethacin effectively blocked the luteolytic action of diethylstilbestrol. These results suggest that the probable mechanism of diethylstilbestrol action in causing luteolysis is mediated via the prostaglandins.
F J Auletta, and
B V Caldwell, and
L Speroff
April 1973,
Endocrinology,
F J Auletta, and
B V Caldwell, and
L Speroff
May 1977,
Prostaglandins,
F J Auletta, and
B V Caldwell, and
L Speroff
May 1981,
Endocrinology,
F J Auletta, and
B V Caldwell, and
L Speroff
February 1984,
Prostaglandins,
F J Auletta, and
B V Caldwell, and
L Speroff
April 1982,
The Journal of clinical endocrinology and metabolism,
F J Auletta, and
B V Caldwell, and
L Speroff
June 1975,
Endocrinology,
F J Auletta, and
B V Caldwell, and
L Speroff
March 1973,
The Journal of clinical endocrinology and metabolism,
F J Auletta, and
B V Caldwell, and
L Speroff
May 1973,
Developmental psychobiology,
F J Auletta, and
B V Caldwell, and
L Speroff
February 1985,
Neuropeptides,
F J Auletta, and
B V Caldwell, and
L Speroff
October 1988,
Biology of reproduction,
