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A standardized disk diffusion test was developed and used to test the susceptibility of 102 strains of Neisseria gonorrhoeae to combinations of trimethoprim and sulfamethoxazole (TMP/SMX) by relating zone diameters of inhibition to minimal inhibitory concentrations (MIC's). MIC's for TMP/SMX in ratios of 1:20 ranged from 0.08/1.52 to 2.5/47.5 mug/ml and zones of inhibition ranged from 34 to 10 mm. The coefficient of correlation (r) was -0.75. For comparison, a regression line was similarly calculated for ampicillin. MIC's ranged from 0.02 to 0.32 mug/ml and zones of inhibition ranged from 50 to 31 mm; r was -0.71. With establishment of MIC breakpoints to define the categories, susceptible, intermediate, and resistant, the disk duffusion test would be as reliable for estimating susceptibility of gonococci to TMP/SMX as for estimating susceptiblity to ampicillin.
R B Prior, and
R J Fass, and
R L Perkins
February 1980,
Antimicrobial agents and chemotherapy,
R B Prior, and
R J Fass, and
R L Perkins
November 1978,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
R B Prior, and
R J Fass, and
R L Perkins
July 2004,
The Journal of antimicrobial chemotherapy,
R B Prior, and
R J Fass, and
R L Perkins
November 1975,
Antimicrobial agents and chemotherapy,
R B Prior, and
R J Fass, and
R L Perkins
May 1976,
Antimicrobial agents and chemotherapy,
R B Prior, and
R J Fass, and
R L Perkins
December 1977,
Journal of medicinal chemistry,
R B Prior, and
R J Fass, and
R L Perkins
February 1997,
Infection and immunity,
R B Prior, and
R J Fass, and
R L Perkins
January 1982,
Reviews of infectious diseases,
R B Prior, and
R J Fass, and
R L Perkins
April 1994,
The Journal of antimicrobial chemotherapy,
R B Prior, and
R J Fass, and
R L Perkins
January 1983,
Chemotherapy,
