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The rearrangements of beta-chain genes of the T cell Ag receptor were examined in 12 CD4- CD8- alpha beta + T cell lines derived from the spleen or thymus of neonatal or adult BALB/c mice. Eleven of the lines were cloned and established from six independent cloning procedures from different mice. Five cloned lines used V beta 9, four cloned lines used V beta 15, and two cloned lines used V beta 7. Nucleotide sequencing of the beta-chain genes showed that clones that used a given V beta were identically rearranged even when they were derived from independent cloning procedures. In the case of V beta 7 and V beta 15 all nucleotides in the V-D-J joining region were in the germ line configuration without N region additions. Rearrangements of the V beta 7, V beta 9, and V beta 15 genes were functional. Each V beta 15 clone also had a homogeneous rearrangement of the V beta 13 gene, which was nonfunctional. The predicted amino acid sequence of the joining regions of the V beta 7, V beta 9, and V beta 15 rearrangements showed homology in four of seven amino acids in the peptide contact region.
I G Schmidt-Wolf, and
O Liang, and
S Dejbakhsh-Jones, and
H Wang, and
L Cheng, and
B Holm, and
R Bell, and
S Strober
June 1994,
Current opinion in immunology,
I G Schmidt-Wolf, and
O Liang, and
S Dejbakhsh-Jones, and
H Wang, and
L Cheng, and
B Holm, and
R Bell, and
S Strober
August 1989,
Journal of immunology (Baltimore, Md. : 1950),
I G Schmidt-Wolf, and
O Liang, and
S Dejbakhsh-Jones, and
H Wang, and
L Cheng, and
B Holm, and
R Bell, and
S Strober
June 1998,
The Journal of investigative dermatology,
I G Schmidt-Wolf, and
O Liang, and
S Dejbakhsh-Jones, and
H Wang, and
L Cheng, and
B Holm, and
R Bell, and
S Strober
January 1992,
Journal of immunology (Baltimore, Md. : 1950),
I G Schmidt-Wolf, and
O Liang, and
S Dejbakhsh-Jones, and
H Wang, and
L Cheng, and
B Holm, and
R Bell, and
S Strober
August 1991,
Cellular immunology,
I G Schmidt-Wolf, and
O Liang, and
S Dejbakhsh-Jones, and
H Wang, and
L Cheng, and
B Holm, and
R Bell, and
S Strober
November 1992,
European journal of immunology,
I G Schmidt-Wolf, and
O Liang, and
S Dejbakhsh-Jones, and
H Wang, and
L Cheng, and
B Holm, and
R Bell, and
S Strober
March 1991,
Lancet (London, England),
I G Schmidt-Wolf, and
O Liang, and
S Dejbakhsh-Jones, and
H Wang, and
L Cheng, and
B Holm, and
R Bell, and
S Strober
August 1992,
Journal of immunology (Baltimore, Md. : 1950),
I G Schmidt-Wolf, and
O Liang, and
S Dejbakhsh-Jones, and
H Wang, and
L Cheng, and
B Holm, and
R Bell, and
S Strober
December 1995,
BioEssays : news and reviews in molecular, cellular and developmental biology,
I G Schmidt-Wolf, and
O Liang, and
S Dejbakhsh-Jones, and
H Wang, and
L Cheng, and
B Holm, and
R Bell, and
S Strober
November 1991,
Human immunology,
