Biomaterial Database

[Autoradiographic studies on the distribution of 3H-pyrithioxine in monkey and mouse (author's transl)]. 1976

G Werner, and G Erdmann, and S Thel

Monkeys and mice received oral and i.p. doses of 3H-labelled pyritinoldihydrochloridemonohydrate (3H-pyrithioxine; Encephabol) and the distribution of radioactivity in the brain and in other organs was investigated by autoradiography. The heaviest label accumulation was present in the pituitary gland. In the monkey the distribution of radioactivity in the brain and in the submandibular gland was different from the distribution found in these organs in the mouse, which may be attributed to the different radioactive metabolites of pyrithioxine produced by the two animal species. Prior to elimination from the body pyrithioxine was completely transformed into metabolites.

UI	MeSH Term	Description	Entries
D007274	Injections, Intraperitoneal	Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.	Intraperitoneal Injections,Injection, Intraperitoneal,Intraperitoneal Injection
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D011725	Pyridines	Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D011746	Pyrithioxin	A neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.	Dipyridoxolyldisulfide,Pyridoxinedisulfide,Pyritinol,Bonifen,Encephabol,Enerbol,Piriditol,Piritinol,Piritoxina,Pyrithioxine,Pyritinol Hydrochloride,Hydrochloride, Pyritinol
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D002143	Callitrichinae	A subfamily in the family CEBIDAE that consists of four genera: CALLITHRIX (marmosets), CALLIMICO (Goeldi's monkey), LEONTOPITHECUS (lion tamarins), and SAGUINUS (long-tusked tamarins). The members of this family inhabit the tropical forests of South and Central America.	Cebuella,Genus Mico,Leontocebus,Mico Genus,Callithricidae,Callitrichidae,Cebuellas,Genus, Mico,Mico, Genus
D004064	Digestive System	A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).	Ailmentary System,Alimentary System
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia