-transparent.png){kind=logo}
An alpha-tocopherol-binding protein has been isolated and purified from rabbit heart cytosol. The purified protein had an apparent molecular mass of 14,200, as derived from SDS-PAGE. The content of the protein in rabbit heart was around 11.8 micrograms per g of tissue. The binding of alpha-tocopherol to the purified protein was rapid, reversible, and saturable. Neither gamma nor delta tocopherol could displace the bound alpha-tocopherol from the protein, suggesting a high specificity for alpha-tocopherol. alpha-Tocopherol-binding protein did not bind oleate. Transfer of alpha-tocopherol from liposomes to mitochondria was stimulated 8-fold in the presence of the binding protein, suggesting that this protein may be involved in the intracellular transport of alpha-tocopherol in the heart.
A K Dutta-Roy, and
M J Gordon, and
D J Leishman, and
B J Paterson, and
G G Duthie, and
W P James
August 1970,
Steroids,
A K Dutta-Roy, and
M J Gordon, and
D J Leishman, and
B J Paterson, and
G G Duthie, and
W P James
August 1980,
The Biochemical journal,
A K Dutta-Roy, and
M J Gordon, and
D J Leishman, and
B J Paterson, and
G G Duthie, and
W P James
March 1993,
FEBS letters,
A K Dutta-Roy, and
M J Gordon, and
D J Leishman, and
B J Paterson, and
G G Duthie, and
W P James
March 1992,
Journal of lipid research,
A K Dutta-Roy, and
M J Gordon, and
D J Leishman, and
B J Paterson, and
G G Duthie, and
W P James
October 1985,
Biochemical and biophysical research communications,
A K Dutta-Roy, and
M J Gordon, and
D J Leishman, and
B J Paterson, and
G G Duthie, and
W P James
August 1982,
Biochemistry,
A K Dutta-Roy, and
M J Gordon, and
D J Leishman, and
B J Paterson, and
G G Duthie, and
W P James
November 1972,
Biochimica et biophysica acta,
A K Dutta-Roy, and
M J Gordon, and
D J Leishman, and
B J Paterson, and
G G Duthie, and
W P James
January 1997,
Methods in enzymology,
A K Dutta-Roy, and
M J Gordon, and
D J Leishman, and
B J Paterson, and
G G Duthie, and
W P James
September 1974,
FEBS letters,
A K Dutta-Roy, and
M J Gordon, and
D J Leishman, and
B J Paterson, and
G G Duthie, and
W P James
September 1974,
Biochemical and biophysical research communications,
