Naftidrofuryl hydrogen oxalate was used for 4 1/2 years in 216 patients with chronic arterial occlusive disease in a surgical clinic. An increase of 1 to 10 times the walking distance could be obtained in over 77% of cases in Fontaine's stage II by a genuine combination treatment with active vascular muscle training and continuous intravenous drip lasting for an average of 28 days. The continuous drip treatment was made possible by a specially designed infusion rucksack 19% of the cases still showed a moderate effect on the walking capacity. By elimination of pain at rest and healing of trophic disorders, it was possible to transfer over 68% of the patients in Stages III and IV to Stage II.