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The article summarized the experience of treatment of 253 cases of trophic ulcers of lower extremities (patients' age 18-82). Surgical method was the main one. Operative interventions were oriented at the main point of pathogenesis in order to close the ulcer defect. Considering the abnormalities of microcirculation as a common component of pathogenesis, the authors substantiate the prolonged arterial infusion via large arterial branches, which were catheterized in 76 patients. It is recommended to perform gnotobiological isolation, immobilized protease, pulsed flow, ultrasonic cavitation, laser irradiation.
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