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[Synthesis of gona-3,5-dienes and studies on their activity for interruption of early pregnancy]. 1993

L Y Zhu, and Z Y Lin, and G D Han
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.

A series of gona-3,5-dienes were synthesized from norgestrel, norethisterone 17 alpha-hydroxyprogesterone and ethisterone via reduction of alpha, beta-unsaturated 3-ketones to allylic alcohols and dehydration with concomitant migration of the double bond. The structures of these gona-3,5-dienes were verified by MS and 1H-NMR spectral data. Pharmacological results showed that compound IVb2 in this series gave rise to significant interruption of early pregnancy in mice. The mechanism of the early pregnancy terminating effect of this compound was discussed.

UI MeSH Term Description Entries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D000021 Abortifacient Agents, Steroidal Steroidal compounds with abortifacient activity. Steroid Abortifacients,Abortifacients, Steroid,Agents, Steroidal Abortifacient,Steroidal Abortifacient Agents
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

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