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The neuropathology of Alzheimer's disease is characterized by the deposition of abnormal protein aggregates. The main constituent of the deposition is beta-amyloid protein. A seminal role of this protein is supported by the discovery of point mutations in the gene of its precursor protein in certain forms of familial Alzheimer's disease. In vitro (cultured neuronal cells), overexpression of the precursor protein or a part of the precursor leads to degeneration of neurons, suggesting neurotoxicity of its derivatives. At this time, all of the reported transgenic mice bearing DNA construct for the precursor or a part of the precursor, however, have not developed convincing pathological changes similar to what is observed in patients with Alzheimer's disease. This interesting discrepancy between in vitro and in vivo suggests suppressors in vivo which ameliorate beta-amyloid precursor protein derivative-mediated neurotoxicity.
K Fukuchi, and
C E Ogburn, and
A C Smith, and
D D Kunkel, and
C E Furlong, and
S S Deeb, and
D Nochlin, and
S M Sumi, and
G M Martin
September 2001,
No to shinkei = Brain and nerve,
K Fukuchi, and
C E Ogburn, and
A C Smith, and
D D Kunkel, and
C E Furlong, and
S S Deeb, and
D Nochlin, and
S M Sumi, and
G M Martin
November 1993,
Behavioural brain research,
K Fukuchi, and
C E Ogburn, and
A C Smith, and
D D Kunkel, and
C E Furlong, and
S S Deeb, and
D Nochlin, and
S M Sumi, and
G M Martin
April 1998,
Neuropathology and applied neurobiology,
K Fukuchi, and
C E Ogburn, and
A C Smith, and
D D Kunkel, and
C E Furlong, and
S S Deeb, and
D Nochlin, and
S M Sumi, and
G M Martin
March 2012,
Current translational geriatrics and experimental gerontology reports,
K Fukuchi, and
C E Ogburn, and
A C Smith, and
D D Kunkel, and
C E Furlong, and
S S Deeb, and
D Nochlin, and
S M Sumi, and
G M Martin
January 2021,
Progress in molecular biology and translational science,
K Fukuchi, and
C E Ogburn, and
A C Smith, and
D D Kunkel, and
C E Furlong, and
S S Deeb, and
D Nochlin, and
S M Sumi, and
G M Martin
September 2019,
Current protocols in neuroscience,
K Fukuchi, and
C E Ogburn, and
A C Smith, and
D D Kunkel, and
C E Furlong, and
S S Deeb, and
D Nochlin, and
S M Sumi, and
G M Martin
January 2010,
International journal of Alzheimer's disease,
K Fukuchi, and
C E Ogburn, and
A C Smith, and
D D Kunkel, and
C E Furlong, and
S S Deeb, and
D Nochlin, and
S M Sumi, and
G M Martin
June 1999,
Molecular medicine today,
K Fukuchi, and
C E Ogburn, and
A C Smith, and
D D Kunkel, and
C E Furlong, and
S S Deeb, and
D Nochlin, and
S M Sumi, and
G M Martin
November 2014,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
K Fukuchi, and
C E Ogburn, and
A C Smith, and
D D Kunkel, and
C E Furlong, and
S S Deeb, and
D Nochlin, and
S M Sumi, and
G M Martin
July 2000,
Biochimica et biophysica acta,
