-transparent.png){kind=logo}
The permeability of the blood-brain barrier to several classes of compounds was studied in rats between the ages of 15 days and 9 weeks. 14C-labelled test substances were injected simultaneously with two reference isotopes, 3H2O and 113mIn-labelled EDTA, into the common carotid artery followed by decapitation 10 s later. There was evidence that a monocarboxylic acid transport system in 15 to 23 day-old rats had a capacity at least six times greater than that present in adult animals. L-Lactate and acetate showed the highest permeability. At all ages there was a constant ratio between L-lactate and (-)D-3-hyroxybutyrate values. D-Glucose permeability increased with age, while that of several amino acids tested was the same in young and adult rats.
J E Cremer, and
L D Braun, and
W H Oldendorf
January 1989,
Reproduction, nutrition, development,
J E Cremer, and
L D Braun, and
W H Oldendorf
January 1993,
Advances in experimental medicine and biology,
J E Cremer, and
L D Braun, and
W H Oldendorf
January 1980,
Advances in experimental medicine and biology,
J E Cremer, and
L D Braun, and
W H Oldendorf
September 1989,
Stroke,
J E Cremer, and
L D Braun, and
W H Oldendorf
January 1976,
Neuroscience,
J E Cremer, and
L D Braun, and
W H Oldendorf
February 1991,
Bollettino della Societa italiana di biologia sperimentale,
J E Cremer, and
L D Braun, and
W H Oldendorf
March 2010,
Endocrinology,
J E Cremer, and
L D Braun, and
W H Oldendorf
November 2008,
Therapeutic advances in neurological disorders,
J E Cremer, and
L D Braun, and
W H Oldendorf
September 1978,
Anesthesiology,
J E Cremer, and
L D Braun, and
W H Oldendorf
January 2018,
Advances in experimental medicine and biology,
