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Citric acid was labeled with 99mTc with an efficiency of > 99%. The biodistribution of 99mTc-citrate was studied in mice with turpentine-induced abscesses in comparison to 67Ga-citrate. The max. abscess/muscle concentration ratios were 4.61 +/- 1.92 (3 h) for 99mTc-citrate and 4.76 +/- 2.04 (4 h) for 67Ga-citrate. Arthritis was induced in 10 rabbits by intra-articular injection of ovalbumin Scintigrams obtained 4 days later and at 3 h post-injection of 99mTc-citrate showed increased activity involving the synovium. The max. arthritic/contralateral knee ratio was 3.19 +/- 1.29 (3 h) and 6.47 +/- 3.71 (24 h) for 99mTc- and 67Ga-citrate, respectively. The blood clearance curve of 99mTc-citrate in rabbits was biexponential with a fast (T1/2 = 36 min) and a slow (T1/2 = 18 h) component, compared to mono-exponential clearance of 67Ga-citrate (T1/2 = 23 h). In 10 patients with rheumatoid arthritis whole-body scintigrams and spot images of involved joints indicated localization of the tracer in inflamed tissues. The mean target-to-soft tissue ratios were 3.04 +/- 0.81 and 4.95 +/- 2.56 for 99mTc-citrate and 99mTc-MDP, respectively. Renal clearance of radioactivity was evident from the scintigrams. Our results demonstrated that 99mTc-citrate is effective as a radiopharmaceutical for the visualization of inflammatory lesions and may be preferred to 67Ga-citrate due to the ideal physical characteristics of the radionuclide, easy preparation, low cost, early accumulation and the preference for the renal route of excretion.
M T Ercan, and
T Aras, and
E Unlenen, and
M Unlü, and
I S Unsal, and
Z Hasçelik
January 1997,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
M T Ercan, and
T Aras, and
E Unlenen, and
M Unlü, and
I S Unsal, and
Z Hasçelik
December 1977,
The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku,
M T Ercan, and
T Aras, and
E Unlenen, and
M Unlü, and
I S Unsal, and
Z Hasçelik
April 1977,
Radiologia diagnostica,
M T Ercan, and
T Aras, and
E Unlenen, and
M Unlü, and
I S Unsal, and
Z Hasçelik
January 1980,
European journal of nuclear medicine,
M T Ercan, and
T Aras, and
E Unlenen, and
M Unlü, and
I S Unsal, and
Z Hasçelik
January 1996,
Problemy tuberkuleza,
M T Ercan, and
T Aras, and
E Unlenen, and
M Unlü, and
I S Unsal, and
Z Hasçelik
January 1986,
European journal of nuclear medicine,
M T Ercan, and
T Aras, and
E Unlenen, and
M Unlü, and
I S Unsal, and
Z Hasçelik
June 1978,
Radiology,
M T Ercan, and
T Aras, and
E Unlenen, and
M Unlü, and
I S Unsal, and
Z Hasçelik
July 1974,
Radiology,
M T Ercan, and
T Aras, and
E Unlenen, and
M Unlü, and
I S Unsal, and
Z Hasçelik
April 1975,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
M T Ercan, and
T Aras, and
E Unlenen, and
M Unlü, and
I S Unsal, and
Z Hasçelik
October 1973,
Annals of surgery,
