BIOMAT Database Logo BIOMAT Database Logo

Cytogenetic studies of primary cultures of esophageal squamous cell carcinoma. 1993

L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
Department of Obstetrics/Gynecology, University of Maryland School of Medicine, Baltimore 21201.

Cytogenetic analysis was performed on primary cultures of 21 squamous cell carcinomas of the esophagus (SCCE). Seven cases exhibited mosaic clonal chromosome abnormalities distributed as follows: two contained tetraploid cell populations, one with t(3;7)(p21;q11); two showed loss of the Y chromosome, one with double minutes; single cases demonstrated der(11)t(4;11)(q?27;q23); add(1)(p35) and del(4)(p12); and del(7)(p13), del(7)(q22q34), and der(11)t(7;11)(p?15;p?13). The remaining 14 cases had apparently normal karyotypes, possibly derived from stromal elements. These results demonstrate numerical abnormalities and the multiple occurrence of rearrangements involving chromosomes 7 and 11 in SCCE.

UI MeSH Term Description Entries
D007621 Karyotyping Mapping of the KARYOTYPE of a cell. Karyotype Analysis Methods,Analysis Method, Karyotype,Analysis Methods, Karyotype,Karyotype Analysis Method,Karyotypings,Method, Karyotype Analysis,Methods, Karyotype Analysis
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009030 Mosaicism The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
D011123 Polyploidy The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc. Polyploid,Polyploid Cell,Cell, Polyploid,Cells, Polyploid,Polyploid Cells,Polyploidies,Polyploids
D002294 Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Squamous Cell Carcinoma,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinomas
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D002872 Chromosome Deletion Actual loss of portion of a chromosome. Monosomy, Partial,Partial Monosomy,Deletion, Chromosome,Deletions, Chromosome,Monosomies, Partial,Partial Monosomies
D004938 Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS. Cancer of Esophagus,Esophageal Cancer,Cancer of the Esophagus,Esophagus Cancer,Esophagus Neoplasm,Neoplasms, Esophageal,Cancer, Esophageal,Cancer, Esophagus,Cancers, Esophageal,Cancers, Esophagus,Esophageal Cancers,Esophageal Neoplasm,Esophagus Cancers,Esophagus Neoplasms,Neoplasm, Esophageal,Neoplasm, Esophagus,Neoplasms, Esophagus
D005260 Female Females

Related Publications

L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
Cytogenetic studies of esophageal carcinoma cell lines.
March 1990, Cancer genetics and cytogenetics,
L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
Cytogenetic heterogeneity and progression of esophageal squamous cell carcinoma.
November 2003, Cancer genetics and cytogenetics,
L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
Primary esophageal squamous cell carcinoma in a cat.
January 2009, Journal of the American Animal Hospital Association,
L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques.
April 2010, Genetics and molecular biology,
L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
Cytogenetic studies of five primary esophageal cancers.
September 1991, Cancer genetics and cytogenetics,
L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
Esophageal squamous cell carcinoma 38 years after primary repair of esophageal atresia.
April 2001, Journal of pediatric surgery,
L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
[Cytogenetic studies on induced squamous cell carcinoma of the skin in mouse].
January 1967, Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete,
L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
Synchronous asymptomatic colonic metastasis from primary esophageal squamous cell carcinoma.
January 2014, Journal of surgical case reports,
L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
Cytogenetic analysis of esophageal squamous cell carcinoma cell lines by comparative genomic hybridization: relationship of cytogenetic aberrations to in vitro cell growth.
March 2000, Cancer genetics and cytogenetics,
L S Rosenblum-Vos, and S J Meltzer, and J Leana-Cox, and S Schwartz
Esophageal squamous cell papilloma, suspected of squamous cell carcinoma.
October 1993, Internal medicine (Tokyo, Japan),
Copied contents to your clipboard!