-transparent.png){kind=logo}
A previous study using intrapleural administration of surface-modified amosite asbestos showed a difference in the number of pleural mesotheliomas induced with C18-hydrocarbon derivatised fibres compared to native amosite asbestos. The study has been repeated with larger groups of animals (30) under specific pathogen free conditions, resulting in an increase in the mean animal survival time for both fibre-treated groups. Under these conditions there was no significant difference between the numbers of pleural mesotheliomas induced by C18 hydrocarbon-modified amosite asbestos and native amosite asbestos. The major difference between the two studies was the mean time to death from tumour of rats exposed to fibres. The C18 amosite treated rats in the first study may not have had a mean survival time long enough to allow mesotheliomas to develop.
P Carthew, and
R E Edwards, and
B M Dorman, and
R C Brown, and
J A Hoskins, and
C F Simpson
January 1989,
IARC scientific publications,
P Carthew, and
R E Edwards, and
B M Dorman, and
R C Brown, and
J A Hoskins, and
C F Simpson
October 1990,
Carcinogenesis,
P Carthew, and
R E Edwards, and
B M Dorman, and
R C Brown, and
J A Hoskins, and
C F Simpson
January 1993,
Polish journal of occupational medicine and environmental health,
P Carthew, and
R E Edwards, and
B M Dorman, and
R C Brown, and
J A Hoskins, and
C F Simpson
January 1980,
IARC scientific publications,
P Carthew, and
R E Edwards, and
B M Dorman, and
R C Brown, and
J A Hoskins, and
C F Simpson
August 1990,
Science (New York, N.Y.),
P Carthew, and
R E Edwards, and
B M Dorman, and
R C Brown, and
J A Hoskins, and
C F Simpson
December 1991,
Annals of the New York Academy of Sciences,
P Carthew, and
R E Edwards, and
B M Dorman, and
R C Brown, and
J A Hoskins, and
C F Simpson
April 2001,
Industrial health,
P Carthew, and
R E Edwards, and
B M Dorman, and
R C Brown, and
J A Hoskins, and
C F Simpson
September 1972,
Archives of environmental health,
P Carthew, and
R E Edwards, and
B M Dorman, and
R C Brown, and
J A Hoskins, and
C F Simpson
January 1988,
Annals of the New York Academy of Sciences,
P Carthew, and
R E Edwards, and
B M Dorman, and
R C Brown, and
J A Hoskins, and
C F Simpson
June 1989,
Lancet (London, England),
