The excimer-laser (XeC1) operating at 308 nm, ablates by means of photochemical mechanisms with minimal thermal injury. Two male patients, 53 years and 67 years, with symptomatic peripheral vascular disease underwent percutaneous transluminal excimer-laser angioplasty (PTPELA). Both of them experienced claudication at a short walking distance and had superficial femoral or initial segmental femoral occlusions from 4 cm to 7 cm in length. The laser emitted 120ns pulses at 20 Hz with delivering 16-18 mJ by 7F and 9F catheter, energy density was about 4mJ/mm. The irradiation time was 157 seconds and 185 seconds respectively. Successful recanalization occurred in our two cases, the residual stenosis were less than 20%. The acute outcome was good without any complications.