Biomaterial Database

[A study on the circadian variation of tissue-type plasminogen activator and its rapid inhibitor in patients with coronary heart disease]. 1993

Z Y Chen

Diagnostic Department, Qingdao Medical College.

In our study, we measured resting tissue-type plasminogen activator(t-PA) activity and resting plasminogen activator inhibitor-1 (PAI-1) activity in 15 healthy men and in 20 patients (male) with coronary heart disease in the morning and evening. Resting t-PA activity was lower (P < 0.05) in controls and was significantly lower (P < 0.001) in patients in the morning compared with that in the evening. In contrast, PAI-1 activity was significantly higher (P < 0.001) in controls and was also significantly higher (P < 0.001) in patients in the morning compared with that in the evening. t-PA activity in patients compared with that in controls was significantly lower (P < 0.05) in the morning and the evening; PAI-1 activity in patients compared with that in controls was significantly higher (P < 0.001) in the morning and the evening. However, t-PA activity was significantly lower (P < 0.05) and PAI-1 activity was significantly higher (P < 0.05) in patients with myocardial infarction compared with anginal patients in the morning. Applying this clinical phenomenon that myocardial infarction and angina have often occurred in the morning, the relationship between time of onset of myocardial infarction and circadian variation of t-PA and PAI-1 was discussed.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010959	Tissue Plasminogen Activator	A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.	Alteplase,Plasminogen Activator, Tissue-Type,T-Plasminogen Activator,Tissue-Type Plasminogen Activator,Actilyse,Activase,Lysatec rt-PA,TTPA,Tisokinase,Tissue Activator D-44,Lysatec rt PA,Lysatec rtPA,Plasminogen Activator, Tissue,Plasminogen Activator, Tissue Type,T Plasminogen Activator,Tissue Activator D 44,Tissue Type Plasminogen Activator
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D003327	Coronary Disease	An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.	Coronary Heart Disease,Coronary Diseases,Coronary Heart Diseases,Disease, Coronary,Disease, Coronary Heart,Diseases, Coronary,Diseases, Coronary Heart,Heart Disease, Coronary,Heart Diseases, Coronary
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D017395	Plasminogen Activator Inhibitor 1	A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.	PAI-1,SERPINE1 Protein,Serpin E1,Type 1 Plasminogen Activator Inhibitor,E1, Serpin,Protein, SERPINE1