-transparent.png){kind=logo}
An autosomal reciprocal translocation (12;21) was found in five seemingly unrelated families in Finland. Three families had had multiple spontaneous abortions and two families had a child with Down's syndrome. The genealogies of the five families were traced using population registries, and four families were found to have a common ancestor born in 1752. Kinship to the fifth family could not be established but its ancestors were traced back to the same rural parishes as those of the four other families. The translocation segregated at the same frequency as normal chromosomes. A statistically insignificant increase in spontaneous abortions was detected when the matings of translocation carriers were compared with non-carrier matings. The increase may however be clinically significant. These results permit more accurate counselling in these and similar translocation families.
S Koskinen, and
T Onnelainen, and
A de la Chapelle, and
J Kere
January 1988,
American journal of medical genetics,
S Koskinen, and
T Onnelainen, and
A de la Chapelle, and
J Kere
November 2000,
American journal of medical genetics,
S Koskinen, and
T Onnelainen, and
A de la Chapelle, and
J Kere
January 1978,
Cytogenetics and cell genetics,
S Koskinen, and
T Onnelainen, and
A de la Chapelle, and
J Kere
January 1974,
Human heredity,
S Koskinen, and
T Onnelainen, and
A de la Chapelle, and
J Kere
February 1988,
Clinical genetics,
S Koskinen, and
T Onnelainen, and
A de la Chapelle, and
J Kere
November 1964,
Bulletin of the Johns Hopkins Hospital,
S Koskinen, and
T Onnelainen, and
A de la Chapelle, and
J Kere
January 2000,
American journal of medical genetics,
S Koskinen, and
T Onnelainen, and
A de la Chapelle, and
J Kere
September 1975,
Zeitschrift fur Kinderheilkunde,
S Koskinen, and
T Onnelainen, and
A de la Chapelle, and
J Kere
June 1978,
Human genetics,
S Koskinen, and
T Onnelainen, and
A de la Chapelle, and
J Kere
September 1973,
Annals of internal medicine,
