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The modulatory effect of arachidonate 5-lipoxygenation on glomerular cell growth was assessed in rat nephrotoxic serum nephritis (NSN). After a single intravenous injection of anti-glomerular basement membrane immune serum, significant increments in glomerular proliferative activity (GPA)--assessed by tritiated thymidine incorporation in short-term glomerular cultures--occurred and were associated with enhanced glomerular cell proliferation, assessed in cortical sections by staining for the presence of proliferating cell nuclear antigen (PCNA) positive cells in glomeruli. Leukocyte depletion induced by x irradiation ameliorated the enhanced GPA and reduced PCNA (+) cell counts. The same effect was observed after treatment of rats with the arachidonate 5-lipoxygenase inhibitor MK886. These observations indicate that in NSN, leukocytes infiltrating glomeruli, and leukocyte-derived arachidonate 5-lipoxygenation eicosanoids promote glomerular cell proliferation.
S H Wu, and
E A Lianos
October 1985,
The Journal of clinical investigation,
S H Wu, and
E A Lianos
January 1989,
Journal of clinical & laboratory immunology,
S H Wu, and
E A Lianos
July 1989,
Kidney international,
S H Wu, and
E A Lianos
January 1977,
Current problems in clinical biochemistry,
S H Wu, and
E A Lianos
January 1983,
Transactions of the Association of American Physicians,
S H Wu, and
E A Lianos
August 1988,
Kidney international,
S H Wu, and
E A Lianos
January 1979,
Virchows Archiv. A, Pathological anatomy and histology,
S H Wu, and
E A Lianos
July 1991,
Kidney international,
S H Wu, and
E A Lianos
January 1989,
Clinical and experimental immunology,
S H Wu, and
E A Lianos
January 1990,
American journal of nephrology,
