-transparent.png){kind=logo}
Differential changes in the expression of PKC isoenzymes in the RA-induced differentiation were noted. As measured by Western blot analysis, our results indicated the expressions of PKC-alpha, and -beta isoenzymes decreased in the cell membrane but increased in the cytosol during the RA-induced granulocytic differentiation. The amounts of PKC-gamma, on the other hand, decreased in the cell membrane while there was no significant changes in the cytosol. Similarly, the expression of PKC-delta was not altered in the cytosol, but was slightly reduced during the SP enhancement of RA-induced differentiation. In contrast, there were virtually little changes in the expression of PKC-epsilon and -zeta in the cell membrane or in the cytosol during the RA-induced differentiation in the absence or presence of SP. Concomitant with the decreased total PKC activity, there was a decline in the generation of sn-1,2-diacylglycerol (DAG) during the RA-induced differentiation. SP, enhancing the RA-induced differentiation, also potentiated the decrease of DAG content.
B Y Yung, and
E K Hui
August 1990,
The Kobe journal of medical sciences,
B Y Yung, and
E K Hui
January 1990,
Cancer research,
B Y Yung, and
E K Hui
February 1998,
Oncogene,
B Y Yung, and
E K Hui
December 1992,
FEBS letters,
B Y Yung, and
E K Hui
January 2004,
Yao xue xue bao = Acta pharmaceutica Sinica,
B Y Yung, and
E K Hui
February 1992,
Journal of biochemistry,
B Y Yung, and
E K Hui
May 1996,
The Journal of biological chemistry,
B Y Yung, and
E K Hui
November 1994,
Naunyn-Schmiedeberg's archives of pharmacology,
B Y Yung, and
E K Hui
December 2004,
FEBS letters,
B Y Yung, and
E K Hui
May 1990,
Molecular and cellular biology,
